Instructor: Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, DACNB, DACBN, FACN

General Schedule: On Demand Videos Replays

Credit Available: 6.5 hours total

Course Description

This course will review the clinical principles of chronic inflammation and its impact on health and disease. The endogenous and exogenous physiological web of inflammatory pathways in chronic illness will be reviewed and summarized. Clinical evaluation and strategies to address specific inflammatory pathways with diet, nutrition, and lifestyle medicine will be presented.

Learning Objectives

  1. Understand the pathophysiology of inflammatory pathways.
  2. Understand exogenous and endogenous pathways of inflammation.
  3. Understand how chronic inflammation impacts chronic disease expression.
  4. Understand the principles of individualized medicine as it applies to chronic inflammation.
  5. Understand how lifestyle medicine can impact inflammatory pathways.
  6. Understand how various diets may impact inflammatory pathways.
  7. Understand how nutraceuticals can be used to impact various inflammatory pathways.
  8. Review how the medical history, physical exam, and laboratory tests can be used to evaluate inflammation.
  9. Understand how to incorporate principles of lifestyle medicine, diet, and nutraceuticals to reduce chronic inflammation
  10. Understand how to monitor inflammation and health after personalized interventional strategies.

Chronic Inflammation Clinical Strategies and Treatment Applications
Course Schedule

Topic 1 – The role of inflammation in chronic conditions (60 minutes)

  • Review of inflammatory immunology.
  • The mechanisms of inflammation with chronic conditions.
  • The impact of chronic inflammation on disease progression and recovery prevention.

Topic 2 – Endogenous Pathways of Inflammation (60 minutes)

  • The role of mucosal immunity in inflammation.
  • The role of innate and adaptive immunity in inflammation.
  • The role of oxidative stress and cellular debris in systemic inflammation.
  • The interplay of antioxidant and adaptive immune systems on modulation of inflammation.

Topic 3 – Exogenous Triggers of Inflammation (60 minutes)

  • The role of environmental pollutants and chemicals in inflammatory pathways.
  • The role of reactive dietary proteins in inflammatory pathways.
  • The role of pathogens and haptens in inflammatory pathways.
  • The impact the psychoneuroimmunology on inflammatory pathways.
  • The role of lifestyle factors in inflammatory pathways.

Topic 4 – The Pathophysiological Web of Chronic Inflammation (60 minutes)

  • Activation of the NF-κB vicious cycles in chronic inflammation.
  • The impact of immunokines, cytokines, prostaglandins, and inflammatory proteins on systemic inflammation.
  • The role of inflammatory pathways in atherosclerosis, bone loss, neurodegeneration, joint degeneration, obesity, and abnormal cellular signaling.

Topic 5 – Clinical Evaluation of Inflammatory pathways (60 minutes)

  • How to identify specific inflammatory pathways from medical history, physical examination, and specific laboratory tests.
  • How to monitor resolution or activation of inflammatory pathways with diagnostic testing.

Topic 6 – Clinical Strategies for Chronic Inflammation (60 minutes)

  • Review of peer-reviewed literature on clinical strategies to dampen chronic inflammation.
  • How to develop personalized diet, nutrition, and lifestyle medicine strategies to modulate case-specific inflammatory pathways.

Topic 7 – Chronic Inflammation Course Review and Question and Answer (30 minutes)