“Mood and Anxiety Disorders Clinical Strategies and Treatment Applications”
Video: New Course – Mood and Anxiety Disorders Course
Live streaming on September 24-25, 2022 from 9:00 am to 5:00 pm (Pacific time)
On Demand video replays after the livestream
$649 Early Bird Registration through August 29th, 9pm (Pacific time)
$749 Pre-Registration August 30th – September 12th, 9pm (Pacific time)
$795 Standard Registration September 13th – September 22nd, 9pm (Pacific time)
CE credits = 12 Hours (see state list below)
Dear Kharrazian Institute Members,
I want to update you on the Mood and Anxiety Disorders course with the current COVID-19 situation.
The course will only be available via livestream on September 24-25, 2022 with access to On-Demand videos after the livestream presentation. As usual, all livestream registrants will have access to the On-Demand videos after the livestream presentation.
Please help us secure our expenses by registering early. We created a $146 Early-Bird discount to encourage you to sign up early.
Early-Bird Registration is only $649 and the regular course registration is $795. Access for all price levels is for 1-year (expiring September 25th, 2023)
I am excited to share my step-by-step clinical approach to Mood and Anxiety Disorders with everyone.
In good health,
Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN and his team
Healthcare is failing tens of millions of patients with mood disorders.
Alternative medicine is failing them with overly simplified approaches.
The Kharrazian Institute Mood and Anxiety Disorders course covers the neurology, neurophysiology, neurochemistry, and neurobiology of mood disorders.
Depression isn’t simply a neurotransmitter issue.
Instead, depression and mood disorders are a dynamic response to various mechanisms that impact the limbic lobe, frontal lobe, and other areas of brain function, including:
- Cerebral blood flow
- Neurochemical activity
- Receptor site responses
- Genetic expressions
- Genetic susceptibility
- Metabolic and immune imbalances, and more.
These individual mechanisms play key roles in major depressive disorder, minor depressive disorder, anxiety disorders, seasonal affective disorder, premenstrual dysphoric disorder, and more.
We will cover the mechanisms of each of these pathways and then go into the web of mood disorders and the underlying mechanisms that most practitioners overlook.
Once we cover the inter-relational pathophysiology, neurophysiology, and web of mood disorders, we then translate that into a step-by-step clinical evaluation.
How do you develop a personalized treatment plan?
This makes the material tangible and not just a theoretical model.
- How do you use questionnaire forms?
- How do you find the individual variables?
- How do you perform an exam?
- What kind of labs do you run?
- What are the key things you look for in their medical history?
We discuss the published research on the nutraceutical, diet, and lifestyle applications that impact mood disorders. We then go through actual patient case studies. I will show you how do you work a patient up from the minute they walk in.
Did you know that major depressive disorder and chronic depression may be early signs of neurodegeneration?
Many people and even doctors believe depression is caused by an imbalance in the neurotransmitters serotonin, dopamine, acetylcholine, or epinephrine — and they do play a role in some basic types of depression.
But when someone suffers from chronic depression for many years, continues to worsen, and doesn’t respond to medication or nutraceutical protocols, they may suffer from a neurodegenerative disease.
In these cases, the clinical approach is to slow down the neurodegenerative processes and increase the brain’s overall efficiency.
Giving patients with major depressive disorder nutraceuticals or an antidepressant to change mood — and then changing the supplement or the drug when the patient doesn’t respond — is a failing model.
Major depressive disorder is a red flag that someone has an unhealthy brain and that their brain is starting to degenerate.
Sometimes it happens in response to a past traumatic brain injury. Sometimes it’s an early symptom of Parkinsonism, early onset Parkinson’s disease, early Alzheimer’s disease, frontal temporal dementia, or other neurodegenerative disorders.
One of the areas we’ll cover in the Kharrazian Institute Mood and Anxiety Disorders course is how to differentiate neurodegeneration and other clinical mechanisms when you see a patient suffering from chronic major depressive disorder.
Anxiety disorders are often secondary to balance issues
Did you know that anxiety disorders can be secondary to balance issues? Related symptoms include vertigo, dizziness, being prone to motion sickness, difficulty being in crowds, and sensitivity to light and sound.
Anxiety results from increased activation of the brain’s limbic centers, which govern such things as fear, anger, emotion, motivation, and memory.
When too much catecholamine, epinephrine, or norepinephrine activate these pathways, or when there is not enough GABAergic activity inhibiting them, anxiety arises.
Many people experience anxiety stemming from the vestibular-cerebellum system, the area of the brain involved with stability. People with vestibular cerebellar disorders have occasional dizziness and worsened balance.
They may tell you they have to hold the handrails walking downstairs and that they trip and fall regularly.
Poor balance activates neurological pathways directly into the limbic system.
When your body feels like it’s falling, the vestibular system sends input to the autonomic centers to increase your heart rate, dilate your pupils, and prepare you for a fall.
Gluten ataxia promotes anxiety through the vestibular-cerebellar system
Gluten ataxia is a condition in which gluten antibodies cross-react with the cerebellum, promoting poor balance. It is commonly seen in those with celiac disease. People with Hashimoto’s hypothyroidism or past brain injuries may also develop autoimmune cross-reactivity in the cerebellum.
It’s common for these individuals to develop chronic anxiety. They’ll experience heightened anxiety in crowded places or while watching a movie with quick screen changes.
A leading cause of mood disorders is…
…shifts in blood sugar balance.
Blood sugar imbalances cause a rollercoaster ride of neurochemical responses throughout the day.
When a person becomes shaky, lightheaded, and “hangry” between meals…
…or if they get really tired and need a nap after eating…
…these are signs of a blood sugar rollercoaster ride that releases different hormones impacting the brain.
When someone’s blood sugar levels drop, they are experiencing a rise in the stress hormones epinephrine, norepinephrine, and cortisol.
On the other hand, insulin surges causing tiredness after meals impacts insulin receptor signaling and catecholamine activity in the brain.
Both of these scenarios can dramatically impact mood, motivation, drive, anxiety, and irritability.
When you see a patient with a mood disorder, you have to look at what is disrupting the mood signaling system, which is based on the integration of hormones, neurotransmitters, and neurological pathways. Even immune-related compounds are involved.
Blood sugar imbalances are one of the many variables we cover that can impact mood.
End-stream neurochemical pathways impact depression and mood disorders
End-stream neurochemical pathways that impact depression and mood disorders involve serotonin, dopamine, GABA, and acetylcholine. Each of these neurochemical pathways has their own expressions within depression:
Dopamine: Can’t motivate, finish tasks, or start tasks; have a hard time with initiation and follow-through.
Serotonin: Can’t experience joy; no longer care about their favorite songs, movies, foods, or social get-togethers.
Epinephrine and norepinephrine: Lack alertness, focus, and drive, and can’t sustain their attention.
GABA: Can’t calm down their brain and have an ongoing restless mind and anxiety.
You need to look for the different features of the depression. These features provide clues to the neurochemical pathways involved.
Then can you work backwards to what caused the breakdown. For example, if it’s related to dopamine activity, explore the nucleus accumbens, dopamine production, MAO clearance of dopamine, and dopamine agonists, such as androgens in males or estrogen in females.
An overly simplified model of giving someone a neurotransmitter supplement doesn’t adequately address these pathways.
Disruptions to the microbiome can impact mood
An explosion of research shows our gut bacteria can impact mood. In animal models they have induced anxiety disorders by sterilizing the gut.
Many types of gut bacteria modulate the synthesis, activation, and clearance of neurotransmitters. The gut microbiome releases hormones, neuropeptides, and neurotransmitters that directly impact the brain via the vagus nerve or by crossing the blood-brain barrier.
Conditions such as intestinal permeability, or leaky gut can cause major depressive disorder, and research shows treating leaky gut with diet and nutrition causes major changes in non-responsive major depressive disorders.
A single drug or nutrient doesn’t work well for depression and mood disorders.
You have to treat the entire web.
The most popular treatment model for depression in both conventional and alternative medicine is a single drug or nutraceutical.
Even if these approaches work, they typically lose their effectiveness because the neurochemical pathways adapt and stop responding.
Effective treatment depends on addressing the web of physiological mechanisms that underlie mood disorders.
You have to evaluate things such as:
- The microbiome
- The blood sugar systems
- Prostaglandin signaling
- Hormone levels
- Brain function
- Signs of neurodegeneration
- Brain oxygenation
These variables impact how our brain functions and its ability to maintain a healthy mood and not be susceptible to trivial things that cause anxiety.
We go over these concepts in the Kharrazian Institute Mood and Anxiety Disorders course to help you break out of the single-drug or single-nutrient model of treating depression and mood disorders.
Dr. Kharrazian is a leading expert in diagnosing and treating chronic conditions
Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN, is a Harvard Medical School trained researcher, clinical research scientist, academic professor, and a functional medicine health care provider. Dr. Kharrazian earned a Master of Medical Science degree (MMSc) in Clinical Investigation from Harvard Medical School, and is a member of the Harvard Medical Alumni Association and the American Association of Immunologists.
Today, Dr. Kharrazian’s clinical models of functional medicine are used by several academic institutions, and thousands of health care clinics and practices providers throughout the world.
He maintains a private practice near San Diego, California, and consults with patients from all over the world who are seeking non-pharmaceutical alternatives. His practice is focused on developing a personalized medical approach using diet, nutrition, and lifestyle approaches.
After decades of analyzing thousands of studies and working with patients in the United States and Europe, Dr. Kharrazian developed never-taught-before clinical strategies to successfully manage mood and anxiety disorders.
Frequently Asked Questions
Do any materials come with this course?
You receive access to all the recorded live videos, presentation slides, published papers, Q&A’s, assessment forms, supplement information, protocols, and all other supporting material for one year after the livestream. This means you can rewatch the recorded lectures as many times as you’d like during this period.
Do I receive continuing education credits for this class?
12 hours of CEs are available for licensed health care practitioners. Please see the bottom of this page for more particulars.
How can I attend this presentation?
You have two options. You can either livestream the presentation from your own home from 9am to 5pm each day. Or you can watch the recorded version, which will be available soon after the livestream.
What if I can’t digest all the information at once?
First, you are given pre-class reading material to begin familiarizing yourself with the material. Then, you have access to the recorded lectures and supporting materials for up to three years (depending on when you purchase). This means you can rewatch lectures as many times as you need.
What if I have questions after the class?
When you register you are invited to join a Members Only Kharrazian Institute Facebook group where you can ask questions and discuss cases with other practitioners.
How can patients in my area learn about me and the fact that I have taken this class?
We have created an online practitioner referral page. Licensed practitioners who have completed all of the Kharrazian Institute courses will be added to the list. Patients can search the list to look for practitioners in their area.
What if parts of the class are unfamiliar to me?
All of the Kharrazian Institute classes are designed to complement one another. As you take all the courses over time you will receive an extraordinarily comprehensive functional medicine education. Different pieces of human physiology, neurology, immunology, and endocrinology all fit together like pieces of a puzzle for one comprehensive understanding of patient evaluation and care.
MARK HYMAN, MD
Dr. Kharrazian has been a prominent educator and highly-respected clinician in the functional medicine community since the inception of functional medicine. He is an expert clinician and an innovator in this field.
CLEVELAND CLINIC, DIRECTOR OF CENTER FOR FUNCTIONAL MEDICINE
CHAIRMAN, INSTITUTE FOR FUNCTIONAL MEDICINE
TEN-TIME NEW YORK TIMES BEST SELLING AUTHOR
JEFFREY BLAND, PHD, FACN, FACB
I have had the pleasure of knowing Dr. Kharrazian for more than a decade and observing his professional growth and impact as a key opinion leader in the field of Functional Neurology. He is voracious in his pursuit of learning and skill development. His pursuit of post-graduate studies at Harvard in research methods has embellished his already significant expertise in systems medicine and its application to Functional Medicine. He has a unique skill in making complex information accessible to his students and patients alike, which is a measure of an individual who is a master of his field. Dr. Kharrazian is a humble, quietly competent leader who leads by example and his presence. The Functional Medicine field is rapidly evolving, and it is through the work and leadership of a select group of professionals, of which Dr. Kharrazian is a recognized leader, that it is growing in both its adoption and successful application to the treatment of complex chronic diseases. It is truly a pleasure to call Dr. Kharrazian both a colleague and friend in our mutual advocacy in the development and application of Functional Medicine.
CO-FOUNDER, INSTITUTE OF FUNCTIONAL MEDICINE
PRESIDENT, PERSONALIZED LIFESTYLE MEDICINE INSTITUTE
Why is Dr. Kharrazian’s Mood and Anxiety course different?
Dr. Kharrazian is an actual clinician who has been successfully treating mood and anxiety disorders in the United States and Europe for more than 20 years.
Dr. Kharrazian has witnessed countless real-life patient scenarios and developed proven strategies to address commonly overlooked issues.
Dr. Kharrazian is both a scientist and an educator.
Dr. Kharrazian has been an innovator in the field of functional medicine since its inception.
Dr. Kharrazian stays continually up-to-date with the latest scientific and medical research.
Dr. Kharrazian was trained as a clinical investigator (Master of Medical Science in Clinical Investigation) at Harvard Medical School and can effectively share with you the most relevant research.
Dr. Kharrazian has published a number of immunology studies in the most respected medical journals in the world.
DAVE PERLMUTTER, MD, FACN, ABIHM
Dr. Kharrazian’s work represents the vanguard in our understanding of the role of lifestyle choices in charting the brain’s destiny. His highly effective educational outreach has opened the door for countless healthcare providers, allowing them to dramatically increase their effectiveness in treating and indeed preventing so many of the pernicious conditions that plague our modern society.
AUTHOR, #1 NEW YORK TIMES BESTSELLING BOOK,
GRAIN BRAIN AND BRAIN MAKER
KELLY BROGAN, MD, ABIHM
Dr. Datis Kharrazian is one of the most powerful clinicians of our time. From the lab to the clinic, he has studied, vetted, and applied his cutting-edge science to heal patients all over the world. I consider him to be a foremost authority in a systems approach to recovery and wellness.
AUTHOR, NEW YORK TIMES BESTSELLING BOOK, A MIND OF YOUR OWN
TERRY WAHLS, MD, IFMCP
Dr. Kharrazian is a brilliant clinician educator who has inspired many, myself included. He is superb at teaching clinicians the power of using functional medicine-oriented history and physical examination to understand and address the root causes of disease and health. Integrating the latest research and years of clinical experience, Dr. Kharrazian, is an international leader in Functional Medicine.
NEW YORK TIMES BEST SELLING AUTHOR OF THE WAHLS PROTOCOL – HOW I BEAT
PROGRESSIVE MS USING PALEO PRINCIPLES AND FUNCTIONAL MEDICINE
CLINICAL PROFESSOR OF MEDICINE, UNIVERSITY OF IOWA, CARVER COLLEGE OF MEDICINE
Register Early and Save
When you register early for the Mood and Anxiety Disorders course you’ll get the most affordable price.
There are two options for attending the Kharrazian Institute’s Mood and Anxiety Disorders course presented by Dr. Datis Kharrazian on September 24-25, 2022: Live streaming video on the website and On Demand videos after the livestream presentation.
All livestream registrants will have access to On Demand Video replays after the live presentation.
Register early and save. Access for all price levels is for 1-year (expiring September 25, 2023)
- Any registrant can renew access to any course for an additional year for $100 instead of the original registration fee.
Registration: Mood and Anxiety Disorders course
LIVE STREAMING ATTENDANCE
September 24-25, 2022
These checkout buttons are for online access to the live streaming presentation plus exams and On Demand video replays after the livestream presentation. At the end of the livestreaming program each day, registrants will be able to access the online exams at the KI learning website. On the KI learning website, you will also have the option to watch the recorded livestreaming presentation (On Demand videos) and take the exams. Watching the livestream and/or watching all videos plus passing both exams is required to be complete for this course and to receive the KI Certificate of Completion. Otherwise you are incomplete for the course. All registrants have 1-year access to all course materials.
Online livestream attendance requires you to log in no later than 9:00 a.m. and log out no sooner than 5:00 p.m. each day, or your ability to earn educational credits may be jeopardized (rules vary from state to state). During the livestream, you will be prompted by a pop-up window to verify your attendance.
Viewing the video content in a group setting will not give you credit for the course. To qualify for credit, you must watch the entire program on your personal computer with your registration email. All online attendance is tracked by our website. KI can only supply minimal attendance information. Please keep track of what you have watched and what you are missing for each module.
Browser update: Recommended browsers for these courses and exams are Safari, Firefox, Edge, and Chrome. Internet Explorer is not recommended. Please update to the newest version of your preferred web browser. If you experience unsatisfactory playback during the live streaming presentation, you may need to restart your computer. Best practice is to restart your computer before the live presentation and avoid unnecessary open applications.
Please note: Your registration email becomes your username for all KI courses and your password will remain the same for all courses. Please prevent auto-fill mistakes on the registration form. Your should use the same registration email for all courses and all required exams. Please do not modify your browser preferences to block cookies or tracking as it may delay credit. Default browser settings are best for all online courses.
Important Notice: Each registration email (username) is intended for an individual user. If multiple users access your KI account from various locations (as tracked by the website), your account will be suspended and all course credits will be voided without refund. Sharing or selling content will void all course credits with no refund.
Please note: CA ACU and NCCAOM registrants must wait until after the CE credits are approved before taking the exams which are required for KI Certificate or CE credits! Please request online learning CE credits from NUHS when you order attendance verification.
Livestreaming webinar attendees should complete their exams no later than 30 days after the livestream for livestream credit otherwise your credit will be via On Demand video replays. Those unable to attend via livestreaming webinar may take the course via On Demand video replays.
For DCs, LAc’s, ND’s (USA only): If you require CE credits (when available) toward your state license, you must purchase the NUHS attendance verification certificate (AVC) or transcripts at the button below after you have completed the course, and after you’ve received the KI Certificate of Completion. Livestream or On demand attendance requires watching all videos and passing both exams for CE credit, or to receive the KI Certificate of Completion. Otherwise you are marked incomplete for the course. Please note: CA ACU and NCCAOM registrants must wait until after the CE credits are approved before taking the exams which are required for KI Certificate or CE credits! Please request Online learning CE credits from NUHS when you order attendance verification.
For Nutritionists: see CE Credits HERE.
IMPORTANT: Our website tracks your livestream participation. CE credit requirements vary from state-to-state. Please check our website for updates.
Please note: For ACNB credit hours – National University of Health Sciences is a Commission for the Accreditation of Graduate Education in Neurology (CAGEN) Approved Provider of Continuing Education. For more information about the ACNB, please log on to ACNB website.
Acupuncture CE’s will be provided by NCCAOM and the Kharrazian Institute has not applied to individual states (except California). Currently, these boards only accept attendance via online replays. To receive credit, please wait until after these boards have approved CE credit for this course, before completing the 2 exams which are required to be complete for the course.
Naturopathic CE’s will be provided by Oregon Board of Naturopathic Medicine and the Kharrazian Institute has not applied to individual states. Please check with your state board to confirm if they will find reciprocity in the Oregon Board of Naturopathic Medicine approval.
Please note: It is your responsibility to know your state’s CE rules in regard to live on-site, live streaming webinar, and online educational programs before enrolling in the Kharrazian Institute program.
Approvals as of July 20, 2022
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Course Dates and Location
The Kharrazian Institute’s Mood and Anxiety Disorders course via livestream is scheduled for September 24-25, 2022, and available via On Demand Videos after the livestream. Please note: Livestream registrants automatically have access to the On Demand video replays and do not need to purchase them separately.
Kharrazian Institute Course Registration Fees
- $649 Early Bird Registration pricing through August 29, 2022, 9pm (Pacific time) – 1 year access to all materials – expires September 25, 2023
- $749 Pre-Registration pricing runs August 30 – September 12, 2022, 9pm (Pacific time) – 1 year access to all materials – expires September 25, 2023
- $795 Standard registration pricing runs September 13 – September 22, 2022, 9pm (Pacific time) – 1 year access to all materials – expires September 25, 2023
Any registrant can renew access to any course for an additional year for a $100.00 fee instead of the original registration fee.
On Demand Video Replays Subscription
Access to On Demand video replays of each course will be available after the livestream. Please note: Livestream registrants automatically have access to the On Demand video replays and do not need to purchase them separately. The On Demand prices are:
$795 per module (Access to all materials for 1 year from your registration date).
Prior to the course, attendees will be emailed a link to course notes and research articles in electronic format. Reading recommendations and discussions to prepare attendees will be conducted at the members-only Kharrazian Institute Facebook group for registrants. Pre-Course material will be available at the KI Learning website (all links will be emailed when you register).
Facebook Discussion Group
Registration for each course includes ongoing access to case discussions on a private Facebook group for registered attendees. Numerous cases and concepts from the course will be presented to help ingrain course concepts and to prepare for the next course.
Details on the exam requirements are located at the KI Learning website. Passing exams is required for this course to receive the KI Certificate of Completion. Otherwise, you are marked incomplete. NUHS has approved credit hours for this program (as available) by live streaming webinars and On Demand video replays. The exams are open-book.
Transcripts will be available on the KI Learning website as a downloadable PDF about 10-15 days after the initial livestream presentation.
Do the courses need to be taken in a certain order?
No. Each course is designed without any previous course requirements. You can choose whichever course topics you are interested in. However, all of the courses are designed to connect with one another if you are interested in learning the bigger picture.
CE Credits and KI Certificate of Completion
Please complete the KI course before you order the CE Credits from National University. You are NOT complete for the course unless you pass both primary exams AND watch the livestream or all videos for both days AND after you have received the KI Certificate of Completion. Attendance via onsite live (when available) does not require exams.
When requesting an attendance verification from NUHS, registrants will need to list the title of the course(s) for which they’d like an attendance verification and through whom they took the course(s): Kharrazian Institute.
Testimonials about the Kharrazian Institute courses
The very first course I attended with Dr. Kharrazian was his Functional Endocrinology course back in 2003 and boy did that ever rock my world. His Kharrazian Institute Neuroinflammation course just did the same thing… but on a MUCH larger scale. It’s a total game changer. Paradigm shifting. I’m 20+ years in practice and I’ve noticed patients are getting so much harder to treat, with much more complex and chronic issues, and now I have a much better understanding why and what to do about it! Dr. K — thank you for putting this revolutionary information together!
I’ve practiced 23 years and one of my biggest pet peeves was “shooting blind.” By this I mean, “It’s been determined by years of clinical use that such and such a remedy is good for the treatment of X.” I always felt inadequate, exposed, and unsure of the variables. I can’t express in words the degree of appreciation I have for your dedication to determining mechanisms, researching studies, and most importantly breaking down this disparate information into readily accessible and mostly easy to understand, maps of malfunctioning physiology. I have found it invaluable. As you repeatedly stressed at your Functional Neurology Seminars program in the past, it’s sloppy clinical work to proceed with treatment until a clear picture of where the dominos fell first is figured out, so the appropriate treatment is arrived at. A million thanks to a fabulous contributor.
This seminar was more eye opening about why some of these chronic failures we’ve all had as practitioners need more of a neuro-metabolic approach and to give yourself and the patient time and give realistic expectations so we both don’t get burned out or disappointed. That was huge for me. Thanks Dr. Kharrazian.
This has been a freaking gorgeous course. Looking forward to the digestive health course in September.
What a blessing to have been able to follow that neuroinflammation course. Full of scientific data but lots of clinical applications that are very helpful for practitioners. I’m very happy to be able to follow that course since nothing is available like this in France. This should be taught in med school. Thank you Dr. Datis Kharrazian!
What a brilliant lecture and very clinical. Hammering home the points and reviewing while we went along really prepared me for the exam. So practical and I will be attending the next two in the series. Very well done. Really can’t say enough good things today. Thanks to everyone involved to pull it off and make livestream possible for me here in Canada.
Dr. Kharrazian has literally given me hope and if I could use one word to describe my weekend it would be “PROFOUND”. I am truly grateful for you!!!
Thanks for the excellent, clinically translatable course; with much appreciation for the lucid organization and abundant supportive documents.