The Kharrazian Institute Is Proud to Present Dr. Datis Kharrazian’s Exciting New Course…

“Longevity and Wellness Optimization Clinical Strategies and Treatment Applications”

Video: Why the Annual Physical Exam has Failed Patients

Live streaming on December 10-11, 2022 from 9:00 am to 5:00 pm (Pacific time)

On Demand video replays after the livestream

$649 Early Bird Registration through November 14th, 9pm (Pacific time)

$749 Pre-Registration November 15th – November 28th, 9pm (Pacific time)

$795 Standard Registration November 29th – December 8th, 9pm (Pacific time)

CE credits = 12 Hours (see state list below)

Dear Kharrazian Institute Members,

I want to update you on the Longevity and Wellness course with the current COVID-19 situation.

The course will only be available via livestream on December 10-11, 2022 with access to On-Demand videos after the livestream presentation. As usual, all livestream registrants will have access to the On-Demand videos after the livestream presentation.

Please help us secure our expenses by registering early. We created a $146 Early-Bird discount to encourage you to sign up early.

Early-Bird Registration is only $649 and the regular course registration is $795. Access for all price levels is for 1-year (expiring December 11, 2023)

I am excited to share my step-by-step clinical approach to Longevity and Wellness Optimization with everyone.

In good health,

Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN and his team

Kharrazian Institute

The annual physical exam is failing the public

The Kharrazian Institute Longevity and Wellness Optimization course covers a multi-factorial approach to longevity that is based on newer research and that is overlooked in the conventional health care system.

The annual exam is failing the public.

Numerous studies have shown that the annual physical exam does very, very little to promote longevity and to identify early disease.

What really happens in the annual physical exam?

  • A very basic history, such as do you drink, exercise, or do drugs?
  • A look at the eyes
  • Quick auscultation
  • Basic blood panel
  • Blood pressure check
  • No screenings for the leading causes of death such as cancer
  • No immunological or cognitive screening
  • Although blood pressure is important, doctors do not look for good markers of cardiovascular disease. Instead, they emphasize lipid panels and the resultant polypharmacy of beta blockers, ACE inhibitors, calcium channel blockers, and statin drugs.

Research shows the annual physical exam does not incorporate the latest technology of laboratory testing, diagnostic markers, and physical examination findings to screen for the most common diseases: Dementia, Alzheimer’s, Parkinson’s disease, cancer, and so forth.

One of the things we’re going to cover in great detail in the Kharrazian Institute Longevity and Wellness Course is what is the latest research on the best early detection markers.

What does an optimal annual workup look like? The old model is obviously not working. We now have significantly better technology that research shows are efficacious and predictive for various diseases.

What makes centenarians, people who are above 100 years old, different than everyone else? Why do some people live into their 100s?

First, centenarians have a high degree of physiological resiliency in immune, endocrine, and cognitive function. This means the body knows how to rebalance itself when it is out of homeostasis. For instance, we saw during the pandemic that people with poor immune resiliency had the worst effects of a viral infection.

Second, researchers have found no single gene impacts longevity. Instead, more than 280 genes can be turned on by environmental, lifestyle, dietary, and pathogenic factors, affecting longevity..

People who live for many years have genetic expression that promotes resiliency. For example, the molecule humanin, which controls and regulates insulin, is high in centenarians compared to other people. Sirtuins regulate cellular homeostasis and health and are important in longevity.

Microbiome diversity is much higher in centenarians than in other people.

They also have better mood resiliency and the ability to stay positive through life’s challenges.

When you look at centenarians compared to everyone else, yes, some genes affect longevity. But environmental and lifestyle factors and resiliency are also key.

We’re going to learn how to evaluate immune, endocrine, and neurological resiliency, identify breakdowns, and how to optimize them in the Kharrazian Institute Longevity and Wellness course.

“Inflammaging” and longevity

The concept of “inflammaging” is a major breakthrough in the field of longevity research. Inflamma-aging refers to chronic inflammation unrelated to pathogens or antigens.

As we age, we build up fragments of DNA, protein, and other cellular debris that create an inflammatory response.

As clinicians, we often see chronic inflammatory conditions in our patients over 40. Their body hurts, their joint hurts, they have neuroinflammation, degenerative pro-inflammatory diseases, and signs of brain degeneration. Then we can go through the list of looking for the different things that may be causing inflammation in them, such as food sensitivities or environmental chemical sensitivities. Yet after exhausting all the possibilities, they still have inflammation.

This is inflammaging—the immune system stays heightened unrelated to any ongoing triggers. It is one of the main mechanisms that determine healthy aging versus unhealthy aging.

How do you address inflammaging? By promoting autophagy to clear out debris cells. Nutraceuticals and anti-inflammatories have little impact on inflammation from accumulated cellular debris.

Strategies such as fasting for more than three days can really turn on autophagy, at least in animal studies. Intermittent fasting does not have as big of an impact on autophagy.

In the Kharrazian Institute Longevity and Wellness course, we’re going to cover inflammaging, how it presents in clinical practice, and strategies to reverse it.

Microbiome health impacts longevity

Research shows direct relationships between microbiome health and longevity. For example, people who lack microbiome diversity tend to become frail and prone to infections and degenerative diseases as they age. Those with diverse microbiomes are more resilient.

The greatest growth in bacterial diversity happens between birth and age three. The next major shift in bacterial populations happens again around age 40. This means diet, exercise, and other lifestyle factors can impact your microbiome diversity.

The types of foods and plant fibers you eat, exposures to environmental toxins, physical activity, degree of alcohol consumption, and genetics all can change the microbiome.

Microbiome diversity is a variable that absolutely should be evaluated in an annual physical exam. Lack of diversity can lead to a 200-fold increased risk of death from the most common diseases.

In the Kharrazian Longevity and Wellness course, we will cover the impact of microbiome health on longevity, how to evaluate microbiome health, and interventions that make a difference.

Both of these scenarios can dramatically impact mood, motivation, drive, anxiety, and irritability.

When you see a patient with a mood disorder, you have to look at what is disrupting the mood signaling system, which is based on the integration of hormones, neurotransmitters, and neurological pathways. Even immune-related compounds are involved.

Blood sugar imbalances are one of the many variables we cover that can impact mood.

Why people develop chronic disease as they age

The field of geroscience studies unhealthy aging. It shows us key variables in why people develop chronic disease as they age.

As we get older, we all experience some degree of bone loss, neurodegeneration, and vascular inflammation. For some, that will progress into dementia, Alzheimer’s disease, atherosclerosis, strokes, heart attacks, and so forth.

The basic model has always been that various mechanisms cause these issues. If someone develops hypertension, insulin resistance, or Alzheimer’s disease, the response of geroscience is that certain pillars of cellular function cause abnormal aging that leads to chronic disease.

This field of research looks at inflammaginghow cellular debris, autophagy and mitophagy, cell-signaling efficiency, and immune resiliency impact aging. Their science of looking at the variables that cause longevity is a completely different approach than the conventional medical paradigm and should not be ignored.

In the Kharrazian Institute Longevity and Wellness course we’re going to cover the philosophies of geroscience, normal versus pathological aging, and how defects in cellular aging may be responsible for chronic diseases.

Possibly the most important course not just for your patients but for YOU

The Kharrazian Institute Course on Longevity and Wellness is probably one of the most important courses you could ever take, not just for your patients but for yourself and your loved ones. One of the key things that you have to understand about longevity is that early detection is key to reversing disease processes.

Even functional medicine doesn’t look at all the different preventive variables. Preventive medicine is more about theory than clinical practice. Yet there has been an explosion of research on predictive biomarkers and examination findings that are not being used clinically.

One of the things we’ll be doing in this course is retraining you—or training you for the first time— on how to look at these variables when doing a patient annual exam and workup.

Second, what is the new research on healthy and unhealthy aging? Which genes are involved? How do these genes express differently? It’s more than getting good sleep, exercising, and eating well. That advice doesn’t always translate to what you actually do with patients.

In the longevity course, we’re going to explore the difference between chronological age and biological age. We’ll talk about aging and gene variants, sirtuins, things that impact the microbiome, resiliency, and the neuroendocrine-immune system. Will look at the research on why centenarians live so long, aging risk factors, and the variables that are critical to evaluate.

By the end of the course, you will have a step-by-step approach to looking at risk factors and detecting disease early in an annual exam for yourself and your patients. You will learn the mechanisms that lead to loss of immune, endocrine, and neurological resiliency that lead to chronic degenerative diseases.

Finally, we’ll go into the field of geroscience, which explores pathophysiological mechanisms that take place in abnormal aging, such as inflammaging, how to identify that in clinical practice, and interventions to change their expression.

Dr. Kharrazian is a leading expert in diagnosing and treating chronic conditions

Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN, is a Harvard Medical School trained researcher, clinical research scientist, academic professor, and a functional medicine health care provider. Dr. Kharrazian earned a Master of Medical Science degree (MMSc) in Clinical Investigation from Harvard Medical School, and is a member of the Harvard Medical Alumni Association and the American Association of Immunologists.

Today, Dr. Kharrazian’s clinical models of functional medicine are used by several academic institutions, and thousands of health care clinics and practices providers throughout the world.

He maintains a private practice near San Diego, California, and consults with patients from all over the world who are seeking non-pharmaceutical alternatives. His practice is focused on developing a personalized medical approach using diet, nutrition, and lifestyle approaches.

After decades of analyzing thousands of studies and working with patients in the United States and Europe, Dr. Kharrazian developed never-taught-before clinical strategies to successfully manage longevity and wellness optimization.

Frequently Asked Questions

Do any materials come with this course?

You receive access to all the recorded live videos, presentation slides, published papers, Q&A’s, assessment forms, supplement information, protocols, and all other supporting material for one year after the livestream. This means you can rewatch the recorded lectures as many times as you’d like during this period.

Do I receive continuing education credits for this class?

12 hours of CEs are available for licensed health care practitioners. Please see the bottom of this page for more particulars.

How can I attend this presentation?

You have two options. You can either livestream the presentation from your own home from 9am to 5pm each day. Or you can watch the recorded version, which will be available soon after the livestream.

What if I can’t digest all the information at once?

First, you are given pre-class reading material to begin familiarizing yourself with the material. Then, you have access to the recorded lectures and supporting materials for up to three years (depending on when you purchase). This means you can rewatch lectures as many times as you need.

What if I have questions after the class?

When you register you are invited to join a Members Only Kharrazian Institute Facebook group where you can ask questions and discuss cases with other practitioners.

How can patients in my area learn about me and the fact that I have taken this class?

We have created an online practitioner referral page. Licensed practitioners who have completed all of the Kharrazian Institute courses will be added to the list. Patients can search the list to look for practitioners in their area.

What if parts of the class are unfamiliar to me?

All of the Kharrazian Institute classes are designed to complement one another. As you take all the courses over time you will receive an extraordinarily comprehensive functional medicine education. Different pieces of human physiology, neurology, immunology, and endocrinology all fit together like pieces of a puzzle for one comprehensive understanding of patient evaluation and care.


Dr. Kharrazian has been a prominent educator and highly-respected clinician in the functional medicine community since the inception of functional medicine. He is an expert clinician and an innovator in this field.



I have had the pleasure of knowing Dr. Kharrazian for more than a decade and observing his professional growth and impact as a key opinion leader in the field of Functional Neurology. He is voracious in his pursuit of learning and skill development. His pursuit of post-graduate studies at Harvard in research methods has embellished his already significant expertise in systems medicine and its application to Functional Medicine. He has a unique skill in making complex information accessible to his students and patients alike, which is a measure of an individual who is a master of his field. Dr. Kharrazian is a humble, quietly competent leader who leads by example and his presence. The Functional Medicine field is rapidly evolving, and it is through the work and leadership of a select group of professionals, of which Dr. Kharrazian is a recognized leader, that it is growing in both its adoption and successful application to the treatment of complex chronic diseases. It is truly a pleasure to call Dr. Kharrazian both a colleague and friend in our mutual advocacy in the development and application of Functional Medicine.


Why is Dr. Kharrazian’s Longevity and Wellness Optimization course different?

Dr. Kharrazian is an actual clinician who has been successfully managing longevity and wellness optimization in the United States and Europe for more than 20 years.

Dr. Kharrazian has witnessed countless real-life patient scenarios and developed proven strategies to address commonly overlooked issues.

Dr. Kharrazian is both a scientist and an educator.

Dr. Kharrazian has been an innovator in the field of functional medicine since its inception.

Dr. Kharrazian stays continually up-to-date with the latest scientific and medical research.

Dr. Kharrazian was trained as a clinical investigator (Master of Medical Science in Clinical Investigation) at Harvard Medical School and can effectively share with you the most relevant research.

Dr. Kharrazian has published a number of immunology studies in the most respected medical journals in the world.


Dr. Kharrazian’s work represents the vanguard in our understanding of the role of lifestyle choices in charting the brain’s destiny. His highly effective educational outreach has opened the door for countless healthcare providers, allowing them to dramatically increase their effectiveness in treating and indeed preventing so many of the pernicious conditions that plague our modern society.



Dr. Datis Kharrazian is one of the most powerful clinicians of our time. From the lab to the clinic, he has studied, vetted, and applied his cutting-edge science to heal patients all over the world. I consider him to be a foremost authority in a systems approach to recovery and wellness.



Dr. Kharrazian is a brilliant clinician educator who has inspired many, myself included. He is superb at teaching clinicians the power of using functional medicine-oriented history and physical examination to understand and address the root causes of disease and health. Integrating the latest research and years of clinical experience, Dr. Kharrazian, is an international leader in Functional Medicine.


Register Early and Save

When you register early for the Longevity and Wellness Optimization course you’ll get the most affordable price.

Attendance options

There are two options for attending the Kharrazian Institute’s Longevity and Wellness Optimization course presented by Dr. Datis Kharrazian on December 10-11, 2022: Live streaming video on the website and On Demand videos after the livestream presentation.

All livestream registrants will have access to On Demand Video replays after the live presentation. 

Register early and save. Access for all price levels is for 1-year (expiring December 11, 2023)

  • Any registrant can renew access to any course for an additional year for $100 instead of the original registration fee.

Registration: Longevity and Wellness Optimization course


  December 10-11, 2022  

These checkout buttons are for online access to the live streaming presentation plus exams and On Demand video replays after the livestream presentation. At the end of the livestreaming program each day, registrants will be able to access the online exams at the KI learning website. On the KI learning website, you will also have the option to watch the recorded livestreaming presentation (On Demand videos) and take the exams. Watching the livestream and/or watching all videos plus passing both exams is required to be complete for this course and to receive the KI Certificate of Completion. Otherwise you are incomplete for the course. All registrants have 1-year access to all course materials.


Online livestream attendance requires you to log in no later than 9:00 a.m. and log out no sooner than 5:00 p.m. each day, or your ability to earn educational credits may be jeopardized (rules vary from state to state). During the livestream, you will be prompted by a pop-up window to verify your attendance.

Viewing the video content in a group setting will not give you credit for the course. To qualify for credit, you must watch the entire program on your personal computer with your registration email. All online attendance is tracked by our website. KI can only supply minimal attendance information. Please keep track of what you have watched and what you are missing for each module.

Browser update: Recommended browsers for these courses and exams are Safari, Firefox, Edge, and Chrome. Internet Explorer is not recommended. Please update to the newest version of your preferred web browser. If you experience unsatisfactory playback during the live streaming presentation, you may need to restart your computer. Best practice is to restart your computer before the live presentation and avoid unnecessary open applications.

Please note: Your registration email becomes your username for all KI courses and your password will remain the same for all courses. Please prevent auto-fill mistakes on the registration form. Your should use the same registration email for all courses and all required exams. Please do not modify your browser preferences to block cookies or tracking as it may delay credit. Default browser settings are best for all online courses.

Important Notice: Each registration email (username) is intended for an individual user. If multiple users access your KI account from various locations (as tracked by the website), your account will be suspended and all course credits will be voided without refund. Sharing or selling content will void all course credits with no refund.


CE credits (12 Hours – USA only) are approved for Livestream (CLICK HERE) or for On Demand Video replays (CLICK HERE).

Please note: CA ACU and NCCAOM registrants must wait until after the CE credits are approved before taking the exams which are required for KI Certificate or CE credits! Please request online learning CE credits from NUHS when you order attendance verification.

IMPORTANT: Livestreaming webinar attendees should complete their exams no later than December 31, 2022 for livestream credit otherwise your credit will be via On Demand video replays. Those unable to attend via livestreaming webinar may take the course via On Demand video replays.

For DCs, LAc’s, ND’s (USA only): If you require CE credits (when available) toward your state license, you must purchase the NUHS attendance verification certificate (AVC) or transcripts at the button below after you have completed the course, and after you’ve received the KI Certificate of Completion. Livestream or On demand attendance requires watching all videos and passing both exams for CE credit, or to receive the KI Certificate of Completion. Otherwise you are marked incomplete for the course. Please note: CA ACU and NCCAOM registrants must wait until after the CE credits are approved before taking the exams which are required for KI Certificate or CE credits! Please request Online learning CE credits from NUHS when you order attendance verification.

For Nutritionists: see CE Credits HERE.

IMPORTANT: Our website tracks your livestream participation. CE credit requirements vary from state-to-state. Please check our website for updates.

Please note: For ACNB credit hours – National University of Health Sciences is a Commission for the Accreditation of Graduate Education in Neurology (CAGEN) Approved Provider of Continuing Education. For more information about the ACNB, please log on to ACNB website.

Acupuncture CE’s will be provided by NCCAOM and the Kharrazian Institute has not applied to individual states (except California). Currently, these boards only accept attendance via online replays. To receive credit, please wait until after these boards have approved CE credit for this course, before completing the 2 exams which are required to be complete for the course.

Naturopathic CE’s will be provided by Oregon Board of Naturopathic Medicine and the Kharrazian Institute has not applied to individual states. Please check with your state board to confirm if they will find reciprocity in the Oregon Board of Naturopathic Medicine approval.

Please note: It is your responsibility to know your state’s CE rules in regard to live on-site, live streaming webinar, and online educational programs before enrolling in the Kharrazian Institute program.

Approvals as of October 18, 2022


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Course Dates and Location

The Kharrazian Institute’s Longevity and Wellness Optimization course via livestream is scheduled for December 10-11, 2022, and available via On Demand Videos after the livestream. Please note: Livestream registrants automatically have access to the On Demand video replays and do not need to purchase them separately.

Kharrazian Institute Course Registration Fees

  • $649 Early Bird Registration pricing through November 14th, 2022, 9pm (Pacific time) – 1 year access to all materials – expires December 11, 2023
  • $749 Pre-Registration pricing runs November 15th – November 28th, 2022, 9pm (Pacific time) – 1 year access to all materials – expires December 11, 2023
  • $795 Standard registration pricing runs November 29th – December 8th, 9pm (Pacific time) – 1 year access to all materials – expires December 11, 2023

Any registrant can renew access to any course for an additional year for a $100.00 fee instead of the original registration fee.

On Demand Video Replays Subscription

Access to On Demand video replays of each course will be available after the livestream. Please note: Livestream registrants automatically have access to the On Demand video replays and do not need to purchase them separately. The On Demand prices are:

Standard Registration:
$795 per module (Access to all materials for 1 year from your registration date).

Pre-Course Information

Prior to the course, attendees will be emailed a link to course notes and research articles in electronic format. Reading recommendations and discussions to prepare attendees will be conducted at the members-only Kharrazian Institute Facebook group for registrants. Pre-Course material will be available at the KI Learning website (all links will be emailed when you register).

Facebook Discussion Group

Registration for each course includes ongoing access to case discussions on a private Facebook group for registered attendees. Numerous cases and concepts from the course will be presented to help ingrain course concepts and to prepare for the next course.


Details on the exam requirements are located at the KI Learning website. Passing exams is required for this course to receive the KI Certificate of Completion. Otherwise, you are marked incomplete. NUHS has approved credit hours for this program (as available) by live streaming webinars and On Demand video replays. The exams are open-book.

Transcripts will be available on the KI Learning website as a downloadable PDF about 10-15 days after the initial livestream presentation.

Do the courses need to be taken in a certain order?

No. Each course is designed without any previous course requirements. You can choose whichever course topics you are interested in. However, all of the courses are designed to connect with one another if you are interested in learning the bigger picture.

CE Credits and KI Certificate of Completion

Please complete the KI course before you order the CE Credits from National University. You are NOT complete for the course unless you pass both primary exams AND watch the livestream or all videos for both days AND after you have received the KI Certificate of Completion. Attendance via onsite live (when available) does not require exams.

When requesting an attendance verification from NUHS, registrants will need to list the title of the course(s) for which they’d like an attendance verification and through whom they took the course(s): Kharrazian Institute.

Testimonials about the Kharrazian Institute courses

– Carri

The very first course I attended with Dr. Kharrazian was his Functional Endocrinology course back in 2003 and boy did that ever rock my world. His Kharrazian Institute Neuroinflammation course just did the same thing… but on a MUCH larger scale. It’s a total game changer. Paradigm shifting. I’m 20+ years in practice and I’ve noticed patients are getting so much harder to treat, with much more complex and chronic issues, and now I have a much better understanding why and what to do about it! Dr. K — thank you for putting this revolutionary information together!

– Christopher

I’ve practiced 23 years and one of my biggest pet peeves was “shooting blind.” By this I mean, “It’s been determined by years of clinical use that such and such a remedy is good for the treatment of X.” I always felt inadequate, exposed, and unsure of the variables. I can’t express in words the degree of appreciation I have for your dedication to determining mechanisms, researching studies, and most importantly breaking down this disparate information into readily accessible and mostly easy to understand, maps of malfunctioning physiology. I have found it invaluable. As you repeatedly stressed at your Functional Neurology Seminars program in the past, it’s sloppy clinical work to proceed with treatment until a clear picture of where the dominos fell first is figured out, so the appropriate treatment is arrived at. A million thanks to a fabulous contributor.

– Steven

This seminar was more eye opening about why some of these chronic failures we’ve all had as practitioners need more of a neuro-metabolic approach and to give yourself and the patient time and give realistic expectations so we both don’t get burned out or disappointed. That was huge for me. Thanks Dr. Kharrazian.

– Diego

This has been a freaking gorgeous course. Looking forward to the digestive health course in September.

– Xavier

What a blessing to have been able to follow that neuroinflammation course. Full of scientific data but lots of clinical applications that are very helpful for practitioners. I’m very happy to be able to follow that course since nothing is available like this in France. This should be taught in med school. Thank you Dr. Datis Kharrazian!

– Judy

What a brilliant lecture and very clinical. Hammering home the points and reviewing while we went along really prepared me for the exam. So practical and I will be attending the next two in the series. Very well done. Really can’t say enough good things today. Thanks to everyone involved to pull it off and make livestream possible for me here in Canada.

– Greg

Dr. Kharrazian has literally given me hope and if I could use one word to describe my weekend it would be “PROFOUND”. I am truly grateful for you!!!

– Lapis

Thanks for the excellent, clinically translatable course; with much appreciation for the lucid organization and abundant supportive documents.

More testimonials


Dr. Kharrazian is one of the greatest minds in the functional medicine space. He’s a trailblazer and an innovator. His courses are gold and his direction is wise. If you’re in healthcare and are ready to be on the right side of history, study with this man.


Dr. Kharrazian is one of the most skilled Functional medicine practitioners in the country. His understanding of interrelationships in physiology puts him in the top tier of Functional Medicine writers and educators in this country.


Datis Kharrazian is truly among the great medical geniuses of our time. His capacity to think outside the box is second to none. He brings cutting-edge insights to the table that others have missed along the way and for this we should be eternally grateful.


Dr. Kharrazian is a leader in functional medicine, always looking to discover the root cause of illness or dysfunction in the body and, most importantly, uncovering novel therapies to improve optimal function.


Dr. Kharrazian’s education gave me the knowledge and confidence to take on complicated chronic cases. I would not have the patient success I have without the information I gained from Dr. Kharrazian. I have taken many seminars by many different doctors but I could not do what I do without the knowledge I gained from Dr. Kharrazian.


Dr. Kharrazian’s education has been pivotal in every aspect of my practice. His curriculum has been my foundation for building seven thriving functional medicine clinics. I couldn’t ask for a more rewarding career path.


In the last decade, I have seen Dr. Kharrazian change the landscape of healthcare. His ability to integrate functional medicine, immunology, and neurology is second to none. Individuals like Dr. Kharrazian come around once in a lifetime. I could not be more honored to learn from him and consider him to be a wonderful mentor. I sincerely believe the Kharrazian Institute will continue to evolve health care.


Dr. Kharrazian’s teachings have made more of a difference than anything else I’ve studied. His way of explaining things has been the most clear and relevant and his treatment recommendations the most efficient and effective. I’m thankful beyond words for all he’s contributed to both my personal health and my professional growth.