“Longevity and Wellness Optimization Clinical Strategies and Treatment Applications”
Why the Annual Physical Exam has Failed Patients
Watch More Longevity and Wellness Videos Below
The annual physical exam is failing the public
The Kharrazian Institute Longevity and Wellness Optimization course covers a multi-factorial approach to longevity that is based on newer research and that is overlooked in the conventional health care system.
The annual exam is failing the public.
Numerous studies have shown that the annual physical exam does very, very little to promote longevity and to identify early disease.
What really happens in the annual physical exam?
- A very basic history, such as do you drink, exercise, or do drugs?
- A look at the eyes
- Quick auscultation
- Basic blood panel
- Blood pressure check
- No screenings for the leading causes of death such as cancer
- No immunological or cognitive screening
- Although blood pressure is important, doctors do not look for good markers of cardiovascular disease. Instead, they emphasize lipid panels and the resultant polypharmacy of beta blockers, ACE inhibitors, calcium channel blockers, and statin drugs.
Research shows the annual physical exam does not incorporate the latest technology of laboratory testing, diagnostic markers, and physical examination findings to screen for the most common diseases: Dementia, Alzheimer’s, Parkinson’s disease, cancer, and so forth.
One of the things we’re going to cover in great detail in the Kharrazian Institute Longevity and Wellness Course is what is the latest research on the best early detection markers.
What does an optimal annual workup look like? The old model is obviously not working. We now have significantly better technology that research shows are efficacious and predictive for various diseases.
What makes centenarians, people who are above 100 years old, different than everyone else? Why do some people live into their 100s?
First, centenarians have a high degree of physiological resiliency in immune, endocrine, and cognitive function. This means the body knows how to rebalance itself when it is out of homeostasis. For instance, we saw during the pandemic that people with poor immune resiliency had the worst effects of a viral infection.
Second, researchers have found no single gene impacts longevity. Instead, more than 280 genes can be turned on by environmental, lifestyle, dietary, and pathogenic factors, affecting longevity..
People who live for many years have genetic expression that promotes resiliency. For example, the molecule humanin, which controls and regulates insulin, is high in centenarians compared to other people. Sirtuins regulate cellular homeostasis and health and are important in longevity.
Microbiome diversity is much higher in centenarians than in other people.
They also have better mood resiliency and the ability to stay positive through life’s challenges.
When you look at centenarians compared to everyone else, yes, some genes affect longevity. But environmental and lifestyle factors and resiliency are also key.
We’re going to learn how to evaluate immune, endocrine, and neurological resiliency, identify breakdowns, and how to optimize them in the Kharrazian Institute Longevity and Wellness course.
“Inflammaging” and longevity
The concept of “inflammaging” is a major breakthrough in the field of longevity research. Inflamma-aging refers to chronic inflammation unrelated to pathogens or antigens.
As we age, we build up fragments of DNA, protein, and other cellular debris that create an inflammatory response.
As clinicians, we often see chronic inflammatory conditions in our patients over 40. Their body hurts, their joint hurts, they have neuroinflammation, degenerative pro-inflammatory diseases, and signs of brain degeneration. Then we can go through the list of looking for the different things that may be causing inflammation in them, such as food sensitivities or environmental chemical sensitivities. Yet after exhausting all the possibilities, they still have inflammation.
This is inflammaging—the immune system stays heightened unrelated to any ongoing triggers. It is one of the main mechanisms that determine healthy aging versus unhealthy aging.
How do you address inflammaging? By promoting autophagy to clear out debris cells. Nutraceuticals and anti-inflammatories have little impact on inflammation from accumulated cellular debris.
Strategies such as fasting for more than three days can really turn on autophagy, at least in animal studies. Intermittent fasting does not have as big of an impact on autophagy.
In the Kharrazian Institute Longevity and Wellness course, we’re going to cover inflammaging, how it presents in clinical practice, and strategies to reverse it.
Microbiome health impacts longevity
Research shows direct relationships between microbiome health and longevity. For example, people who lack microbiome diversity tend to become frail and prone to infections and degenerative diseases as they age. Those with diverse microbiomes are more resilient.
The greatest growth in bacterial diversity happens between birth and age three. The next major shift in bacterial populations happens again around age 40. This means diet, exercise, and other lifestyle factors can impact your microbiome diversity.
The types of foods and plant fibers you eat, exposures to environmental toxins, physical activity, degree of alcohol consumption, and genetics all can change the microbiome.
Microbiome diversity is a variable that absolutely should be evaluated in an annual physical exam. Lack of diversity can lead to a 200-fold increased risk of death from the most common diseases.
In the Kharrazian Longevity and Wellness course, we will cover the impact of microbiome health on longevity, how to evaluate microbiome health, and interventions that make a difference.
Both of these scenarios can dramatically impact mood, motivation, drive, anxiety, and irritability.
When you see a patient with a mood disorder, you have to look at what is disrupting the mood signaling system, which is based on the integration of hormones, neurotransmitters, and neurological pathways. Even immune-related compounds are involved.
Blood sugar imbalances are one of the many variables we cover that can impact mood.
Why people develop chronic disease as they age
The field of geroscience studies unhealthy aging. It shows us key variables in why people develop chronic disease as they age.
As we get older, we all experience some degree of bone loss, neurodegeneration, and vascular inflammation. For some, that will progress into dementia, Alzheimer’s disease, atherosclerosis, strokes, heart attacks, and so forth.
The basic model has always been that various mechanisms cause these issues. If someone develops hypertension, insulin resistance, or Alzheimer’s disease, the response of geroscience is that certain pillars of cellular function cause abnormal aging that leads to chronic disease.
This field of research looks at inflammaging—how cellular debris, autophagy and mitophagy, cell-signaling efficiency, and immune resiliency impact aging. Their science of looking at the variables that cause longevity is a completely different approach than the conventional medical paradigm and should not be ignored.
In the Kharrazian Institute Longevity and Wellness course we’re going to cover the philosophies of geroscience, normal versus pathological aging, and how defects in cellular aging may be responsible for chronic diseases.
Possibly the most important course not just for your patients but for YOU
The Kharrazian Institute Course on Longevity and Wellness is probably one of the most important courses you could ever take, not just for your patients but for yourself and your loved ones. One of the key things that you have to understand about longevity is that early detection is key to reversing disease processes.
Even functional medicine doesn’t look at all the different preventive variables. Preventive medicine is more about theory than clinical practice. Yet there has been an explosion of research on predictive biomarkers and examination findings that are not being used clinically.
One of the things we’ll be doing in this course is retraining you—or training you for the first time— on how to look at these variables when doing a patient annual exam and workup.
Second, what is the new research on healthy and unhealthy aging? Which genes are involved? How do these genes express differently? It’s more than getting good sleep, exercising, and eating well. That advice doesn’t always translate to what you actually do with patients.
In the longevity course, we’re going to explore the difference between chronological age and biological age. We’ll talk about aging and gene variants, sirtuins, things that impact the microbiome, resiliency, and the neuroendocrine-immune system. Will look at the research on why centenarians live so long, aging risk factors, and the variables that are critical to evaluate.
By the end of the course, you will have a step-by-step approach to looking at risk factors and detecting disease early in an annual exam for yourself and your patients. You will learn the mechanisms that lead to loss of immune, endocrine, and neurological resiliency that lead to chronic degenerative diseases.
Finally, we’ll go into the field of geroscience, which explores pathophysiological mechanisms that take place in abnormal aging, such as inflammaging, how to identify that in clinical practice, and interventions to change their expression.
Dr. Kharrazian is a leading expert in diagnosing and treating chronic conditions
Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN, is a Harvard Medical School trained researcher, clinical research scientist, academic professor, and a functional medicine health care provider. Dr. Kharrazian earned a Master of Medical Science degree (MMSc) in Clinical Investigation from Harvard Medical School, and is a member of the Harvard Medical Alumni Association and the American Association of Immunologists.
Today, Dr. Kharrazian’s clinical models of functional medicine are used by several academic institutions, and thousands of health care clinics and practices providers throughout the world.
Dr. Kharrazian consults with patients from all over the world who are seeking non-pharmaceutical alternatives. His practice is focused on developing a personalized medical approach using diet, nutrition, and lifestyle approaches.
After decades of analyzing thousands of studies and working with patients in the United States and Europe, Dr. Kharrazian developed never-taught-before clinical strategies to successfully manage longevity and wellness optimization.
Frequently Asked Questions
Do any materials come with this course?
You receive access to all the recorded live videos, presentation slides, published papers, Q&A’s, assessment forms, supplement information, protocols, and all other supporting material for one year after the livestream. This means you can rewatch the recorded lectures as many times as you’d like during this period.
Do I receive continuing education credits for this class?
12 hours of CEs are available for licensed health care practitioners. Please see the bottom of this page for more particulars.
What if I can’t digest all the information at once?
First, you are given pre-class reading material to begin familiarizing yourself with the material. Then, you have access to the recorded lectures and supporting materials for up to three years (depending on when you purchase). This means you can rewatch lectures as many times as you need.
What if I have questions after the class?
When you register you are invited to join a Members Only Kharrazian Institute Facebook group where you can ask questions and discuss cases with other practitioners.
How can patients in my area learn about me and the fact that I have taken this class?
We have created an online practitioner referral page. Licensed practitioners who have completed all of the Kharrazian Institute courses will be added to the list. Patients can search the list to look for practitioners in their area.
What if parts of the class are unfamiliar to me?
All of the Kharrazian Institute classes are designed to complement one another. As you take all the courses over time you will receive an extraordinarily comprehensive functional medicine education. Different pieces of human physiology, neurology, immunology, and endocrinology all fit together like pieces of a puzzle for one comprehensive understanding of patient evaluation and care.
MARK HYMAN, MD
Dr. Kharrazian has been a prominent educator and highly-respected clinician in the functional medicine community since the inception of functional medicine. He is an expert clinician and an innovator in this field.
CLEVELAND CLINIC, DIRECTOR OF CENTER FOR FUNCTIONAL MEDICINE
CHAIRMAN, INSTITUTE FOR FUNCTIONAL MEDICINE
TEN-TIME NEW YORK TIMES BEST SELLING AUTHOR
JEFFREY BLAND, PHD, FACN, FACB
I have had the pleasure of knowing Dr. Kharrazian for more than a decade and observing his professional growth and impact as a key opinion leader in the field of Functional Neurology. He is voracious in his pursuit of learning and skill development. His pursuit of post-graduate studies at Harvard in research methods has embellished his already significant expertise in systems medicine and its application to Functional Medicine. He has a unique skill in making complex information accessible to his students and patients alike, which is a measure of an individual who is a master of his field. Dr. Kharrazian is a humble, quietly competent leader who leads by example and his presence. The Functional Medicine field is rapidly evolving, and it is through the work and leadership of a select group of professionals, of which Dr. Kharrazian is a recognized leader, that it is growing in both its adoption and successful application to the treatment of complex chronic diseases. It is truly a pleasure to call Dr. Kharrazian both a colleague and friend in our mutual advocacy in the development and application of Functional Medicine.
CO-FOUNDER, INSTITUTE OF FUNCTIONAL MEDICINE
PRESIDENT, PERSONALIZED LIFESTYLE MEDICINE INSTITUTE
Why is Dr. Kharrazian’s Longevity and Wellness Optimization course different?
Dr. Kharrazian is an actual clinician who has been successfully managing longevity and wellness optimization in the United States and Europe for more than 20 years.
Dr. Kharrazian has witnessed countless real-life patient scenarios and developed proven strategies to address commonly overlooked issues.
Dr. Kharrazian is both a scientist and an educator.
Dr. Kharrazian has been an innovator in the field of functional medicine since its inception.
Dr. Kharrazian stays continually up-to-date with the latest scientific and medical research.
Dr. Kharrazian was trained as a clinical investigator (Master of Medical Science in Clinical Investigation) at Harvard Medical School and can effectively share with you the most relevant research.
Dr. Kharrazian has published a number of immunology studies in the most respected medical journals in the world.
DAVE PERLMUTTER, MD, FACN, ABIHM
Dr. Kharrazian’s work represents the vanguard in our understanding of the role of lifestyle choices in charting the brain’s destiny. His highly effective educational outreach has opened the door for countless healthcare providers, allowing them to dramatically increase their effectiveness in treating and indeed preventing so many of the pernicious conditions that plague our modern society.
AUTHOR, #1 NEW YORK TIMES BESTSELLING BOOK,
GRAIN BRAIN AND BRAIN MAKER
KELLY BROGAN, MD, ABIHM
Dr. Datis Kharrazian is one of the most powerful clinicians of our time. From the lab to the clinic, he has studied, vetted, and applied his cutting-edge science to heal patients all over the world. I consider him to be a foremost authority in a systems approach to recovery and wellness.
AUTHOR, NEW YORK TIMES BESTSELLING BOOK, A MIND OF YOUR OWN
TERRY WAHLS, MD, IFMCP
Dr. Kharrazian is a brilliant clinician educator who has inspired many, myself included. He is superb at teaching clinicians the power of using functional medicine-oriented history and physical examination to understand and address the root causes of disease and health. Integrating the latest research and years of clinical experience, Dr. Kharrazian, is an international leader in Functional Medicine.
NEW YORK TIMES BEST SELLING AUTHOR OF THE WAHLS PROTOCOL – HOW I BEAT
PROGRESSIVE MS USING PALEO PRINCIPLES AND FUNCTIONAL MEDICINE
CLINICAL PROFESSOR OF MEDICINE, UNIVERSITY OF IOWA, CARVER COLLEGE OF MEDICINE
On Demand Registration
Longevity and Wellness Optimization Clinical Strategies and Treatment Applications
Welcome to ON DEMAND registration for KI Course Twelve – Longevity and Wellness Optimization. After registration, you will have one-year access to all videos and course materials from the date of your registration. IMPORTANT: You should take all exams in a timely manner in order to get the appropriate credit (if available) from NUHS, or to receive the KI Certificate of Completion.
Current status for CE credits via ON Demand video replays for state licenses is located HERE.
For Nutritionists: see CE Credits HERE.
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Attendance via Online Replays
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ON DEMAND Registration
Longevity and Wellness Optimization Course
These checkout buttons (in one single payment) reserve ON DEMAND access to Course Twelve on the KI Learning website for all course materials, videos, testing, and transcripts. After registration, you will have a one-year access to all materials from the date of your registration. If you have questions, please email us HERE.
PLEASE NOTE: IF YOU HAVE AN ACTIVE KI SUBSCRIPTION, YOU DO NOT NEED TO REGISTER FOR THIS COURSE AS YOU WILL HAVE ACCESS TO THE LIVESTREAM AND ON DEMAND REPLAYS AFTER THE LIVESTREAM AS LONG AS YOUR SUBSCRIPTION IS ACTIVE.
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IMPORTANT NOTE: After registration, you will receive an email titled Important Login Info: Kharrazian Institute… which contains your login credentials for immediate access to all course materials and videos. After watching all videos and successfully completing the online examinations for each course, you will receive a “KI Certificate of Completion”. Otherwise, you are incomplete for the course.
These checkout buttons below are for 2 monthly payments (1st payment at checkout; 2nd payment is 30 days after checkout) reserve ON DEMAND access to Course Twelve on the KI Learning website for all course materials, videos, testing, and transcripts. Please note: Coupon codes and PayPal are not available with this payment option. Remaining information is the same as above.
IMPORTANT NOTE: After registration, you will receive an email titled Important Login Info: Kharrazian Institute… which contains your login credentials for immediate access to all course materials and videos. After watching all videos and successfully completing the online examinations for each course, you will receive a “KI Certificate of Completion”. Otherwise, you are incomplete for the course.
CE Credits and KI Certificate of Completion
Please complete the KI course before you order the CE Credits from National University. You are NOT complete for the course unless you pass both primary exams AND watch the livestream or all videos for both days AND after you have received the KI Certificate of Completion. Attendance via onsite live (when available) does not require exams.
When requesting an attendance verification from NUHS, registrants will need to list the title of the course(s) for which they’d like an attendance verification and through whom they took the course(s): Kharrazian Institute.
Testimonials about the Kharrazian Institute courses
More testimonials
PEDRAM SHOJAI, OMD
Dr. Kharrazian is one of the greatest minds in the functional medicine space. He’s a trailblazer and an innovator. His courses are gold and his direction is wise. If you’re in healthcare and are ready to be on the right side of history, study with this man.
AUTHOR, NEW YORK TIMES BESTSELLING BOOK, THE URBAN MONK
FOUNDER OF WELL.ORG
DAVID MUSNICK, MD
Dr. Kharrazian is one of the most skilled Functional medicine practitioners in the country. His understanding of interrelationships in physiology puts him in the top tier of Functional Medicine writers and educators in this country.
FACULTY OF THE INSTITUTE FOR FUNCTIONAL MEDICINE
NORA GEDGAUDAS, CNS, NTP, BCHN
Datis Kharrazian is truly among the great medical geniuses of our time. His capacity to think outside the box is second to none. He brings cutting-edge insights to the table that others have missed along the way and for this we should be eternally grateful.
AUTHOR, PRIMAL BODY, PRIMAL MIND AND PRIMAL FAT BURNER
ELIZABETH BOHAM, MD, RD
Dr. Kharrazian is a leader in functional medicine, always looking to discover the root cause of illness or dysfunction in the body and, most importantly, uncovering novel therapies to improve optimal function.
MEDICAL DIRECTOR OF THE ULTRAWELLNESS CENTER
MARK FLANNERY, DC, MS, BS
Dr. Kharrazian’s education gave me the knowledge and confidence to take on complicated chronic cases. I would not have the patient success I have without the information I gained from Dr. Kharrazian. I have taken many seminars by many different doctors but I could not do what I do without the knowledge I gained from Dr. Kharrazian.
DIRECTOR OF HEALTH WISE CLINICAL NUTRITION
JOSHUA REDD, DC, MS
Dr. Kharrazian’s education has been pivotal in every aspect of my practice. His curriculum has been my foundation for building seven thriving functional medicine clinics. I couldn’t ask for a more rewarding career path.
FOUNDER OF RED RIVER HEALTH AND WELLNESS CENTER
AUTHOR, THE TRUTH ABOUT LOW THYROID
SHANE STEADMAN, DC, DACNB, DCBCN, CNS
In the last decade, I have seen Dr. Kharrazian change the landscape of healthcare. His ability to integrate functional medicine, immunology, and neurology is second to none. Individuals like Dr. Kharrazian come around once in a lifetime. I could not be more honored to learn from him and consider him to be a wonderful mentor. I sincerely believe the Kharrazian Institute will continue to evolve health care.
DIRECTOR, INTEGRATED HEALTH SYSTEMS AND INTEGRATED BRAIN CENTERS
