“Chronic Inflammation Clinical Strategies and Treatment Applications”
Video: Introduction to Chronic Inflammation course
Livestream on May 11, 2024 from 9 am to 5:35 pm (Pacific time)
On Demand video replays after the livestream
$395 for 1-year access
Registration closes May 9th at 9pm (Pacific time)
CE credits = 6.5 Hours (see state list below)
Chronic Inflammation Course
The Kharrazian Institute Chronic Inflammation Clinical Strategies and Treatment Applications course is designed to expand your understanding of chronic inflammation pathways, knowledge that is crucial for the effective treatment of chronic health conditions.
Everyone knows inflammation is bad, but as a clinician, you want to understand all the different pathways of inflammation because they all have different effects.
Many practitioners have their preferred anti-inflammatory approaches, such as fish oil, vitamin D, combinations of various nutraceuticals, and various diets. However, relying solely on nutraceutical and dietary approaches can be inefficient. This course will equip you with a more comprehensive understanding of inflammation, enabling you to adopt more effective treatment strategies.
When evaluating inflammation and why it develops, you must understand prostaglandin and essential fatty acid pathways. For instance, the roles of prostanoids, eicosanoids, and leukotrienes are completely independent of T-cell-generated TH-17 or TH-1 pathways, IgE mast cell, or complement protein pathways. Each of these pathways depends on a different approach to clinical management.
In this comprehensive course, we will meticulously dissect all the known pathways of inflammation. We will delve into:
- How they clinically present
- How to conduct labs to identify them
- How to use evidence-based strategies to address each of the pathways
This thorough understanding will equip you with the knowledge to make informed treatment decisions.
For example, suppose someone has chronic mast cell IgE-mediated inflammation driving their osteoarthritis. Fish oil may have a minimal impact in this situation. The pathways themselves will determine the most appropriate treatment interventions.
We will go beyond the obvious fact that inflammation promotes chronic diseases and into how to dissect inflammation thoroughly.
What does the latest research show about how to modulate the impact of each of these inflammatory pathways? Then, how do you apply that in clinical practice?
By attending this course, you will gain insights that can significantly improve your patient workup and education. More importantly, you will learn practical strategies for applying this knowledge in your clinical practice. I believe it will revolutionize how you approach your patients’ chronic conditions, making a tangible difference in their health outcomes.
Lack of physical activity is one of the most overlooked causes of chronic inflammation
One of the most overlooked pathways of chronic inflammation is lack of movement. When people think of inflammation, they think of a leaky gut, food sensitivities, environmental chemicals, and pathogens. However, lack of movement and activity creates a significant inflammatory cascade.
Much research, including studies published in reputable journals, shows that becoming sedentary severely upregulates the inflammatory system. Additionally, body fat releases adipokines that turn on the IL-6 inflammatory pathway. IL-6 then triggers the NF-κB pathway in a self-perpetuating inflammatory vicious cycle.
In a clinical setting, a patient could have an underlying inflammatory condition, such as irritable bowel syndrome, an inflammatory joint condition, or an autoimmune disease.
Lack of movement and activity creates a significant inflammatory cascade.
When they have a flare-up, you may assume it’s related to an antigen or trigger. However, if they become sedentary, that could be the trigger. Research has found that even simple muscle contraction can quickly resolve this. They’ve discovered that muscles release myokines, which modulate IL-6, and quickly shut down this NF-κB pathway. Not many things aggressively shut down NF-κB pathways to this degree.
Reducing inflammation doesn’t have to be complicated or time-consuming. Simple actions like isometric contractions, which anyone can do, can have a dramatic impact. To do this, contract your different muscle groups for 30 seconds each for five minutes. This is a small, manageable action that can yield significant results.
We’re going to delve into these concepts and specific pathways of inflammation in the Kharrazian Institute course on Chronic Inflammation. I encourage you to attend and get updated on all the latest research on these specific inflammatory responses and applications to manage them.
Inflammaging
“Inflammaging,” a term coined to describe the combination of aging and inflammation, is a crucial concept for clinicians to grasp. Inflammaging occurs when cellular debris becomes trapped in tissues and muscles, including organ systems and the brain. A significant manifestation of inflammaging is chronic muscle pain throughout the body.
When proteins and debris build up in tissue, the cells must clear them out. However, when cells become senescent due to aging, they may lose the ability to clear this debris from cells efficiently. This compromises immune macrophages, leading to chronic inflammation and chronic pain.
When patients with chronic muscle pain throughout their body continue to suffer despite a strict anti-inflammatory diet, removing antigens and triggers, and taking good quality anti-inflammatory compounds, it may be necessary to also address inflammaging pathways.
Strategies to dampen inflammaging pathways include:
- Promoting autophagy, a process of cellular self-digestion
- Promoting mitophagy, the selective removal of damaged mitochondria
- Promoting mitochondrial efficiency
- Encouraging daily physical movement
Inflammaging has been shown to be a precursor to disease development. Longevity studies demonstrate that the diseases most associated with premature death, such as cardiovascular disease and cancers, are directly linked to the degree of inflammatory mediators. In other words, the higher the degree of inflammation, the greater the risk for these conditions.
When confronting inflammation clinically, it’s crucial to grasp these concepts. You can implement strategies such as using cold shock proteins and heat shock proteins through therapies like cold plunges and saunas. Promoting autophagy through time-restricted eating and intermittent fasting is another strategy.
Why do some people respond well to anti-inflammatory strategies while others don’t?
Why do some people respond well to anti-inflammatory strategies while others don’t?
Each patient presents a unique set of triggers that influence their chronic inflammatory load, underscoring the necessity for personalized care.
Examples include:
- Prostaglandin pathways that include prostanoids, leukotrienes, and eicosanoids
- Periodontal disease and gum inflammation
- Dysbiosis
- High insulin levels
- Autoimmunity
- Immune barrier permeability
- Poor prostaglandin balance
- Mast cell responses
- Depleted antioxidant levels, etc.
As a clinician, your role is crucial in understanding the various endogenous mechanisms that can activate inflammation in each patient. This knowledge is key to guiding their health journey effectively.
Understanding these variables, combined with their history, laboratory analyses, and other factors, gives a baseline blueprint of their overall inflammatory vulnerability.
A patient’s lifestyle factors, such as increased body fat, a sedentary lifestyle, and high insulin, can significantly influence their susceptibility to inflammation. Your guidance in these areas can make a profound difference in their health.
The upcoming Kharrazian Institute course, Chronic Inflammation Clinical Strategies and Treatment Applications, is designed to equip you with the necessary tools. I’ll guide you on how to make a comprehensive checklist of all the different variables that are known inflammatory triggers in patients with chronic health issues.
This information is essential not only for you as the practitioner but also for your patient.
Open to licensed practitioners, medical doctors, nurse practitioners, health coaches, and other health professionals.
Three variables of chronic inflammation
As a clinician, your role in identifying and addressing chronic inflammation in your patients is crucial. It’s important to be aware of whether your patient is dealing with acute reoccurring inflammation triggers such as a chronic infection, their list of independent inflammatory variables (these are factors that can cause inflammation on their own), and whether they have a robust anti-inflammatory response.
An experienced clinician can narrow the physiological pathways of chronic inflammation down to three primary variables:
1. Reoccurring patterns of acute inflammation.
2. Ongoing triggers of multiple inflammatory pathways
3. An inability to dampen inflammatory pathways
We have several possible pathways of inflammation.
They include:
- Prostaglandin pathways that include prostanoids, leukotrienes, and eicosanoids
- Histamines
- The complement protein matrix
- T-cell responses
- Adipocyte activity
- Dysbiosis and poor gut health
Chronic inflammation is a complex condition, a puzzle with multiple pieces. More than one pathway can operate, and a combined load of multiple inflammatory pathways that persist over a long period can lead to chronic inflammation. This complexity presents a challenge that you, as a clinician, are uniquely equipped to address, and it’s this challenge that keeps our profession dynamic and rewarding.
Every person will have some inflammatory load, but what are their anti-inflammatory mechanisms? What are their heat shock protein activities, cold shock protein activities, T-cell activity, and prostaglandin balance?
The Kharrazian Institute course on chronic inflammation is designed to equip you with the knowledge and tools to identify each of these variables and then to tip the scale for someone in a pro-inflammatory state to an anti-inflammatory state. We will guide you through each step, ensuring you feel confident in your ability to address chronic inflammation in your patients.
Dr. Kharrazian is a leading expert in chronic inflammation
Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN, is a Harvard Medical School trained researcher, clinical research scientist, academic professor, and a functional medicine health care provider. Dr. Kharrazian earned a Master of Medical Science degree (MMSc) in Clinical Investigation from Harvard Medical School, and is a member of the Harvard Medical Alumni Association and the American Association of Immunologists.
Today, Dr. Kharrazian’s clinical models of functional medicine are used by several academic institutions, and thousands of health care clinics and practices providers throughout the world.
He maintains a private practice near San Diego, California, and consults with patients from all over the world who are seeking non-pharmaceutical alternatives. His practice is focused on developing a personalized medical approach using diet, nutrition, and lifestyle approaches.
Frequently Asked Questions
Do any materials come with this course?
You receive access to all the recorded live videos, presentation slides, published papers, Q&A’s, assessment forms, supplement information, protocols, and all other supporting material for one year after the livestream. This means you can rewatch the recorded lectures as many times as you’d like during this period.
Do I receive continuing education credits for this class?
6.5 hours of CEs are available for licensed health care practitioners (exceptions noted on CE credits page). Please see the bottom of this page for more particulars.
How can I attend this presentation?
You have two options. You can either livestream the presentation, or you can watch the recorded version, which will be available soon after the livestream.
What if I can’t digest all the information at once?
First, you are given pre-class reading material to begin familiarizing yourself with the material. Then, you have access to the recorded lectures and supporting materials for up to three years (depending on when you purchase). This means you can rewatch lectures as many times as you need.
What if I have questions after the class?
When you register you are invited to join a Members Only Kharrazian Institute Facebook group where you can ask questions and discuss cases with other practitioners.
How can patients in my area learn about me and the fact that I have taken this class?
We have created an online practitioner referral page. Licensed practitioners who have completed all of the Kharrazian Institute courses will be added to the list. Patients can search the list to look for practitioners in their area.
What if parts of the class are unfamiliar to me?
All of the Kharrazian Institute classes are designed to complement one another. As you take all the courses over time you will receive an extraordinarily comprehensive functional medicine education. Different pieces of human physiology, neurology, immunology, and endocrinology all fit together like pieces of a puzzle for one comprehensive understanding of patient evaluation and care.
MARK HYMAN, MD
Dr. Kharrazian has been a prominent educator and highly-respected clinician in the functional medicine community since the inception of functional medicine. He is an expert clinician and an innovator in this field.
CLEVELAND CLINIC, DIRECTOR OF CENTER FOR FUNCTIONAL MEDICINE
CHAIRMAN, INSTITUTE FOR FUNCTIONAL MEDICINE
TEN-TIME NEW YORK TIMES BEST SELLING AUTHOR
JEFFREY BLAND, PHD, FACN, FACB
I have had the pleasure of knowing Dr. Kharrazian for more than a decade and observing his professional growth and impact as a key opinion leader in the field of Functional Neurology. He is voracious in his pursuit of learning and skill development. His pursuit of post-graduate studies at Harvard in research methods has embellished his already significant expertise in systems medicine and its application to Functional Medicine. He has a unique skill in making complex information accessible to his students and patients alike, which is a measure of an individual who is a master of his field. Dr. Kharrazian is a humble, quietly competent leader who leads by example and his presence. The Functional Medicine field is rapidly evolving, and it is through the work and leadership of a select group of professionals, of which Dr. Kharrazian is a recognized leader, that it is growing in both its adoption and successful application to the treatment of complex chronic diseases. It is truly a pleasure to call Dr. Kharrazian both a colleague and friend in our mutual advocacy in the development and application of Functional Medicine.
CO-FOUNDER, INSTITUTE OF FUNCTIONAL MEDICINE
PRESIDENT, PERSONALIZED LIFESTYLE MEDICINE INSTITUTE
Why is Dr. Kharrazian’s Chronic Inflammation course different?
Dr. Kharrazian is an actual clinician who has been successfully treating chronic inflammation in the United States and Europe for more than 20 years.
Dr. Kharrazian has witnessed countless real-life patient scenarios and developed proven strategies to address commonly overlooked issues.
Dr. Kharrazian is both a scientist and an educator.
Dr. Kharrazian has been an innovator in the field of functional medicine since its inception.
Dr. Kharrazian stays continually up-to-date with the latest scientific and medical research.
Dr. Kharrazian was trained as a clinical investigator (Master of Medical Science in Clinical Investigation) at Harvard Medical School and can effectively share with you the most relevant research.
Dr. Kharrazian has published a number of immunology studies in the most respected medical journals in the world.
DAVE PERLMUTTER, MD, FACN, ABIHM
Dr. Kharrazian’s work represents the vanguard in our understanding of the role of lifestyle choices in charting the brain’s destiny. His highly effective educational outreach has opened the door for countless healthcare providers, allowing them to dramatically increase their effectiveness in treating and indeed preventing so many of the pernicious conditions that plague our modern society.
AUTHOR, #1 NEW YORK TIMES BESTSELLING BOOK,
GRAIN BRAIN AND BRAIN MAKER
KELLY BROGAN, MD, ABIHM
Dr. Datis Kharrazian is one of the most powerful clinicians of our time. From the lab to the clinic, he has studied, vetted, and applied his cutting-edge science to heal patients all over the world. I consider him to be a foremost authority in a systems approach to recovery and wellness.
AUTHOR, NEW YORK TIMES BESTSELLING BOOK, A MIND OF YOUR OWN
TERRY WAHLS, MD, IFMCP
Dr. Kharrazian is a brilliant clinician educator who has inspired many, myself included. He is superb at teaching clinicians the power of using functional medicine-oriented history and physical examination to understand and address the root causes of disease and health. Integrating the latest research and years of clinical experience, Dr. Kharrazian, is an international leader in Functional Medicine.
NEW YORK TIMES BEST SELLING AUTHOR OF THE WAHLS PROTOCOL – HOW I BEAT
PROGRESSIVE MS USING PALEO PRINCIPLES AND FUNCTIONAL MEDICINE
CLINICAL PROFESSOR OF MEDICINE, UNIVERSITY OF IOWA, CARVER COLLEGE OF MEDICINE
Register Early
When you register for the Chronic Inflammation course you’ll have 1 year access.
Attendance options
There are two options for attending the Kharrazian Institute Chronic Inflammation course presented by Dr. Datis Kharrazian on May 11, 2024: Live streaming video on the website and On Demand videos after the livestream presentation.
All livestream registrants will have access to On Demand Video replays after the livestream presentation.
Registration: Chronic Inflammation course
LIVE STREAMING ATTENDANCE
May 11, 2024
These checkout buttons are for online access to the live streaming presentation plus exam and On Demand video replays after the livestream presentation. At the end of the livestreaming program, registrants will be able to access the online exam at the KI learning website. On the KI learning website, you will also have the option to watch the recorded livestreaming presentation (On Demand videos) and take the exam. Watching the livestream and/or watching all videos plus passing the exam is required to be complete for this course and to receive the KI Certificate of Completion. Otherwise you are incomplete for the course.
CLICK HERE TO READ GENERAL ATTENDANCE INFORMATION
Online livestream attendance requires you to log in no later than 9:00 a.m. and log out no sooner than 5:35 p.m. each day, or your ability to earn educational credits may be jeopardized (rules vary from state to state). During the livestream, you will be prompted by a pop-up window to verify your attendance.
Viewing the video content in a group setting will not give you credit for the course. To qualify for credit, you must watch the entire program on your personal computer with your registration email. All online attendance is tracked by our website. KI can only supply minimal attendance information. Please keep track of what you have watched and what you are missing for each course.
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Please note: Your registration email becomes your username for all KI courses and your password will remain the same for all courses. Please prevent auto-fill mistakes on the registration form. Your should use the same registration email for all courses and all required exam(s). Please do not modify your browser preferences to block cookies or tracking as it may delay credit. Default browser settings are best for all online courses.
Important Notice: Each registration email (username) is intended for an individual user. If multiple users access your KI account from various locations (as tracked by the website), your account will be suspended and all course credits will be voided without refund. Sharing or selling content will void all course credits with no refund.
CLICK HERE TO READ EDUCATION CREDITS INFORMATION
CE credits (6.5 Hours – USA only) are approved for Livestream (CLICK HERE) or for On Demand Video replays (CLICK HERE). See the links for exceptions.
Please note: CA ACU and NCCAOM registrants must wait until after the CE credits are approved before taking the exam which is required for KI Certificate or CE credits! Please request online learning CE credits from NUHS when you order attendance verification.
IMPORTANT: Livestreaming webinar attendees should complete their exam within 30 days after the livestream for livestream credit otherwise your credit will be via online replays. Those unable to attend via livestreaming webinar may take the course via On Demand video replays.
For DCs, LAc’s, ND’s (USA only): If you require CE credits (when available) toward your state license, you must purchase the NUHS transcript at the button below after you have completed the course, and after you’ve received the KI Certificate of Completion. Livestream or On Demand attendance requires watching all videos and passing the exam for CE credit, or to receive the KI Certificate of Completion. Otherwise you are marked incomplete for the course. Please note: CA ACU and NCCAOM registrants must wait until after the CE credits are approved before taking the exam which is required for KI Certificate or CE credits! Please request Online learning CE credits from NUHS when you order attendance verification.
IMPORTANT: Our website tracks your livestream participation. CE credit requirements vary from state-to-state. Please check our website for updates.
Acupuncture CE’s will be provided by NCCAOM and the Kharrazian Institute has not applied to individual states (except California). Currently, the CA ACU board only accepts attendance via online replays. To receive credit, please wait until after these boards have approved CE credit for this course, before completing the exam which is required to be complete for the course.
Naturopathic CE’s will be provided by Oregon Board of Naturopathic Medicine and the Kharrazian Institute has not applied to individual states. Please check with your state board to confirm if they will find reciprocity in the Oregon Board of Naturopathic Medicine approval.
Please note: It is your responsibility to know your state’s CE rules in regard to live streaming webinar, and online educational programs before enrolling in the Kharrazian Institute program.
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Course Dates and Location
The Kharrazian Institute Essentials of Functional Medicine course via livestream is scheduled for May 11, 2024, and available via On Demand Videos after the livestream. Please note: Livestream registrants automatically have access to the On Demand video replays and do not need to purchase them separately.
Kharrazian Institute Chronic Inflammation Course Registration Fees
- $395 for livestream and online replays after the livestream (1-year access)
On Demand Video Replays Subscription
Access to On Demand video replays of each course will be available after the livestream. Please note: Livestream registrants automatically have access to the On Demand video replays and do not need to purchase them separately.
Pre-Course Information
Prior to the course, attendees will be emailed a link to course notes and research articles in electronic format. Reading recommendations and discussions to prepare attendees will be conducted at the members-only Kharrazian Institute Facebook group for registrants. Pre-Course material will be available at the KI Learning website (all links will be emailed when you register).
Facebook Discussion Group
Registration for each course includes ongoing access to case discussions on a private Facebook group for registered attendees. Numerous cases and concepts from the course will be presented to help ingrain course concepts and to prepare for the next course.
Exams
Details on the exam requirements are located at the KI Learning website. Passing the exam is required for this course to receive the KI Certificate of Completion. Otherwise, you are marked incomplete. NUHS has approved credit hours for this program (as available) by live streaming webinars and On Demand video replays. The exam is open-book.
Transcripts will be available on the KI Learning website as a downloadable PDF about 10-15 days after the initial livestream presentation.
Do the courses need to be taken in a certain order?
No. Each course is designed without any previous course requirements. You can choose whichever course topics you are interested in. However, all of the courses are designed to connect with one another if you are interested in learning the bigger picture.
CE Credits and KI Certificate of Completion
Please complete the KI course before you order the CE Credits from National University. You are NOT complete for the course unless you pass the exam AND watch the livestream or all videos AND after you have received the KI Certificate of Completion.
When requesting an attendance verification from NUHS, registrants will need to list the title of the course(s) for which they’d like an attendance verification and through whom they took the course(s): Kharrazian Institute.
Testimonials about the Kharrazian Institute courses
More testimonials
PEDRAM SHOJAI, OMD
Dr. Kharrazian is one of the greatest minds in the functional medicine space. He’s a trailblazer and an innovator. His courses are gold and his direction is wise. If you’re in healthcare and are ready to be on the right side of history, study with this man.
AUTHOR, NEW YORK TIMES BESTSELLING BOOK, THE URBAN MONK
FOUNDER OF WELL.ORG
DAVID MUSNICK, MD
Dr. Kharrazian is one of the most skilled Functional medicine practitioners in the country. His understanding of interrelationships in physiology puts him in the top tier of Functional Medicine writers and educators in this country.
FACULTY OF THE INSTITUTE FOR FUNCTIONAL MEDICINE
NORA GEDGAUDAS, CNS, NTP, BCHN
Datis Kharrazian is truly among the great medical geniuses of our time. His capacity to think outside the box is second to none. He brings cutting-edge insights to the table that others have missed along the way and for this we should be eternally grateful.
AUTHOR, PRIMAL BODY, PRIMAL MIND AND PRIMAL FAT BURNER
ELIZABETH BOHAM, MD, RD
Dr. Kharrazian is a leader in functional medicine, always looking to discover the root cause of illness or dysfunction in the body and, most importantly, uncovering novel therapies to improve optimal function.
MEDICAL DIRECTOR OF THE ULTRAWELLNESS CENTER
MARK FLANNERY, DC, MS, BS
Dr. Kharrazian’s education gave me the knowledge and confidence to take on complicated chronic cases. I would not have the patient success I have without the information I gained from Dr. Kharrazian. I have taken many seminars by many different doctors but I could not do what I do without the knowledge I gained from Dr. Kharrazian.
DIRECTOR OF HEALTH WISE CLINICAL NUTRITION
JOSHUA REDD, DC, MS
Dr. Kharrazian’s education has been pivotal in every aspect of my practice. His curriculum has been my foundation for building seven thriving functional medicine clinics. I couldn’t ask for a more rewarding career path.
FOUNDER OF RED RIVER HEALTH AND WELLNESS CENTER
AUTHOR, THE TRUTH ABOUT LOW THYROID
SHANE STEADMAN, DC, DACNB, DCBCN, CNS
In the last decade, I have seen Dr. Kharrazian change the landscape of healthcare. His ability to integrate functional medicine, immunology, and neurology is second to none. Individuals like Dr. Kharrazian come around once in a lifetime. I could not be more honored to learn from him and consider him to be a wonderful mentor. I sincerely believe the Kharrazian Institute will continue to evolve health care.
DIRECTOR, INTEGRATED HEALTH SYSTEMS AND INTEGRATED BRAIN CENTERS
