The Kharrazian Institute Is Proud to Present Dr. Datis Kharrazian’s Exciting New Course…

“Chronic Inflammation Clinical Strategies and Treatment Applications”

Introduction to Chronic Inflammation Course

Watch More Chronic Inflammation Videos Below

Video 2: The most overlooked pathway of chronic Inflammation - Is inflammation promoted by lack of movement

The most overlooked pathway of chronic Inflammation – Is inflammation promoted by lack of movement

Video 3: Inflammaging – How your own tissues promote inflammation

Inflammaging – How your own tissues promote inflammation

Video 4: Why are some people more or less responsive to anti-inflammatory strategies

Why are some people more or less responsive to anti-inflammatory strategies

Video 5: Chronic Inflammation Simplified into 3 Variables

Chronic Inflammation Simplified into 3 Variables

Chronic Inflammation Course

The Kharrazian Institute Chronic Inflammation Clinical Strategies and Treatment Applications course is designed to expand your understanding of chronic inflammation pathways, knowledge that is crucial for the effective treatment of chronic health conditions.

Everyone knows inflammation is bad, but as a clinician, you want to understand all the different pathways of inflammation because they all have different effects.

Many practitioners have their preferred anti-inflammatory approaches, such as fish oil, vitamin D, combinations of various nutraceuticals, and various diets. However, relying solely on nutraceutical and dietary approaches can be inefficient. This course will equip you with a more comprehensive understanding of inflammation, enabling you to adopt more effective treatment strategies.

When evaluating inflammation and why it develops, you must understand prostaglandin and essential fatty acid pathways. For instance, the roles of prostanoids, eicosanoids, and leukotrienes are completely independent of T-cell-generated TH-17 or TH-1 pathways, IgE mast cell, or complement protein pathways. Each of these pathways depends on a different approach to clinical management.

In this comprehensive course, we will meticulously dissect all the known pathways of inflammation. We will delve into:

  • How they clinically present
  • How to conduct labs to identify them
  • How to use evidence-based strategies to address each of the pathways

This thorough understanding will equip you with the knowledge to make informed treatment decisions.

For example, suppose someone has chronic mast cell IgE-mediated inflammation driving their osteoarthritis. Fish oil may have a minimal impact in this situation. The pathways themselves will determine the most appropriate treatment interventions.

We will go beyond the obvious fact that inflammation promotes chronic diseases and into how to dissect inflammation thoroughly.

What does the latest research show about how to modulate the impact of each of these inflammatory pathways? Then, how do you apply that in clinical practice?

By attending this course, you will gain insights that can significantly improve your patient workup and education. More importantly, you will learn practical strategies for applying this knowledge in your clinical practice. I believe it will revolutionize how you approach your patients’ chronic conditions, making a tangible difference in their health outcomes.

Lack of physical activity is one of the most overlooked causes of chronic inflammation

One of the most overlooked pathways of chronic inflammation is lack of movement. When people think of inflammation, they think of a leaky gut, food sensitivities, environmental chemicals, and pathogens. However, lack of movement and activity creates a significant inflammatory cascade.

Much research, including studies published in reputable journals, shows that becoming sedentary severely upregulates the inflammatory system. Additionally, body fat releases adipokines that turn on the IL-6 inflammatory pathway. IL-6 then triggers the NF-κB pathway in a self-perpetuating inflammatory vicious cycle.

In a clinical setting, a patient could have an underlying inflammatory condition, such as irritable bowel syndrome, an inflammatory joint condition, or an autoimmune disease.

Lack of movement and activity creates a significant inflammatory cascade.

When they have a flare-up, you may assume it’s related to an antigen or trigger. However, if they become sedentary, that could be the trigger. Research has found that even simple muscle contraction can quickly resolve this. They’ve discovered that muscles release myokines, which modulate IL-6, and quickly shut down this NF-κB pathway. Not many things aggressively shut down NF-κB pathways to this degree.

Reducing inflammation doesn’t have to be complicated or time-consuming. Simple actions like isometric contractions, which anyone can do, can have a dramatic impact. To do this, contract your different muscle groups for 30 seconds each for five minutes. This is a small, manageable action that can yield significant results.

We’re going to delve into these concepts and specific pathways of inflammation in the Kharrazian Institute course on Chronic Inflammation. I encourage you to attend and get updated on all the latest research on these specific inflammatory responses and applications to manage them.

Inflammaging

“Inflammaging,” a term coined to describe the combination of aging and inflammation, is a crucial concept for clinicians to grasp. Inflammaging occurs when cellular debris becomes trapped in tissues and muscles, including organ systems and the brain. A significant manifestation of inflammaging is chronic muscle pain throughout the body.

When proteins and debris build up in tissue, the cells must clear them out. However, when cells become senescent due to aging, they may lose the ability to clear this debris from cells efficiently. This compromises immune macrophages, leading to chronic inflammation and chronic pain.

When patients with chronic muscle pain throughout their body continue to suffer despite a strict anti-inflammatory diet, removing antigens and triggers, and taking good quality anti-inflammatory compounds, it may be necessary to also address inflammaging pathways.

Strategies to dampen inflammaging pathways include:

  • Promoting autophagy, a process of cellular self-digestion
  • Promoting mitophagy, the selective removal of damaged mitochondria
  • Promoting mitochondrial efficiency
  • Encouraging daily physical movement

Inflammaging has been shown to be a precursor to disease development. Longevity studies demonstrate that the diseases most associated with premature death, such as cardiovascular disease and cancers, are directly linked to the degree of inflammatory mediators. In other words, the higher the degree of inflammation, the greater the risk for these conditions.

When confronting inflammation clinically, it’s crucial to grasp these concepts. You can implement strategies such as using cold shock proteins and heat shock proteins through therapies like cold plunges and saunas. Promoting autophagy through time-restricted eating and intermittent fasting is another strategy.

Why do some people respond well to anti-inflammatory strategies while others don’t?

Why do some people respond well to anti-inflammatory strategies while others don’t?

Each patient presents a unique set of triggers that influence their chronic inflammatory load, underscoring the necessity for personalized care.

Examples include:

  • Prostaglandin pathways that include prostanoids, leukotrienes, and eicosanoids
  • Periodontal disease and gum inflammation
  • Dysbiosis
  • High insulin levels
  • Autoimmunity
  • Immune barrier permeability
  • Poor prostaglandin balance
  • Mast cell responses
  • Depleted antioxidant levels, etc.

As a clinician, your role is crucial in understanding the various endogenous mechanisms that can activate inflammation in each patient. This knowledge is key to guiding their health journey effectively.

Understanding these variables, combined with their history, laboratory analyses, and other factors, gives a baseline blueprint of their overall inflammatory vulnerability.

A patient’s lifestyle factors, such as increased body fat, a sedentary lifestyle, and high insulin, can significantly influence their susceptibility to inflammation. Your guidance in these areas can make a profound difference in their health.

The upcoming Kharrazian Institute course, Chronic Inflammation Clinical Strategies and Treatment Applications, is designed to equip you with the necessary tools. I’ll guide you on how to make a comprehensive checklist of all the different variables that are known inflammatory triggers in patients with chronic health issues.

This information is essential not only for you as the practitioner but also for your patient.

Open to licensed practitioners, medical doctors, nurse practitioners, health coaches, and other health professionals.

Three variables of chronic inflammation

As a clinician, your role in identifying and addressing chronic inflammation in your patients is crucial. It’s important to be aware of whether your patient is dealing with acute reoccurring inflammation triggers such as a chronic infection, their list of independent inflammatory variables (these are factors that can cause inflammation on their own), and whether they have a robust anti-inflammatory response.

An experienced clinician can narrow the physiological pathways of chronic inflammation down to three primary variables:

1. Reoccurring patterns of acute inflammation.

2. Ongoing triggers of multiple inflammatory pathways

3. An inability to dampen inflammatory pathways

We have several possible pathways of inflammation.

They include:

  • Prostaglandin pathways that include prostanoids, leukotrienes, and eicosanoids
  • Histamines
  • The complement protein matrix
  • T-cell responses
  • Adipocyte activity
  • Dysbiosis and poor gut health

Chronic inflammation is a complex condition, a puzzle with multiple pieces. More than one pathway can operate, and a combined load of multiple inflammatory pathways that persist over a long period can lead to chronic inflammation. This complexity presents a challenge that you, as a clinician, are uniquely equipped to address, and it’s this challenge that keeps our profession dynamic and rewarding.

Every person will have some inflammatory load, but what are their anti-inflammatory mechanisms? What are their heat shock protein activities, cold shock protein activities, T-cell activity, and prostaglandin balance?

The Kharrazian Institute course on chronic inflammation is designed to equip you with the knowledge and tools to identify each of these variables and then to tip the scale for someone in a pro-inflammatory state to an anti-inflammatory state. We will guide you through each step, ensuring you feel confident in your ability to address chronic inflammation in your patients.

Dr. Kharrazian is a leading expert in chronic inflammation

Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN, is a Harvard Medical School trained researcher, clinical research scientist, academic professor, and a functional medicine health care provider. Dr. Kharrazian earned a Master of Medical Science degree (MMSc) in Clinical Investigation from Harvard Medical School, and is a member of the Harvard Medical Alumni Association and the American Association of Immunologists.

Today, Dr. Kharrazian’s clinical models of functional medicine are used by several academic institutions, and thousands of health care clinics and practices providers throughout the world.

He maintains a private practice near San Diego, California, and consults with patients from all over the world who are seeking non-pharmaceutical alternatives. His practice is focused on developing a personalized medical approach using diet, nutrition, and lifestyle approaches.

Frequently Asked Questions

Do any materials come with this course?

You receive access to all the recorded live videos, presentation slides, published papers, Q&A’s, assessment forms, supplement information, protocols, and all other supporting material for one year after the livestream. This means you can rewatch the recorded lectures as many times as you’d like during this period.

Do I receive continuing education credits for this class?

6.5 hours of CEs are available for licensed health care practitioners (exceptions noted on CE credits page). Please see the bottom of this page for more particulars.

What if I can’t digest all the information at once?

First, you are given pre-class reading material to begin familiarizing yourself with the material. Then, you have access to the recorded lectures and supporting materials for up to three years (depending on when you purchase). This means you can rewatch lectures as many times as you need.

What if I have questions after the class?

When you register you are invited to join a Members Only Kharrazian Institute Facebook group where you can ask questions and discuss cases with other practitioners.

How can patients in my area learn about me and the fact that I have taken this class?

We have created an online practitioner referral page. Licensed practitioners who have completed all of the Kharrazian Institute courses will be added to the list. Patients can search the list to look for practitioners in their area.

What if parts of the class are unfamiliar to me?

All of the Kharrazian Institute classes are designed to complement one another. As you take all the courses over time you will receive an extraordinarily comprehensive functional medicine education. Different pieces of human physiology, neurology, immunology, and endocrinology all fit together like pieces of a puzzle for one comprehensive understanding of patient evaluation and care.

MARK HYMAN, MD

Dr. Kharrazian has been a prominent educator and highly-respected clinician in the functional medicine community since the inception of functional medicine. He is an expert clinician and an innovator in this field.

CLEVELAND CLINIC, DIRECTOR OF CENTER FOR FUNCTIONAL MEDICINE
CHAIRMAN, INSTITUTE FOR FUNCTIONAL MEDICINE
TEN-TIME NEW YORK TIMES BEST SELLING AUTHOR

JEFFREY BLAND, PHD, FACN, FACB

I have had the pleasure of knowing Dr. Kharrazian for more than a decade and observing his professional growth and impact as a key opinion leader in the field of Functional Neurology. He is voracious in his pursuit of learning and skill development. His pursuit of post-graduate studies at Harvard in research methods has embellished his already significant expertise in systems medicine and its application to Functional Medicine. He has a unique skill in making complex information accessible to his students and patients alike, which is a measure of an individual who is a master of his field. Dr. Kharrazian is a humble, quietly competent leader who leads by example and his presence. The Functional Medicine field is rapidly evolving, and it is through the work and leadership of a select group of professionals, of which Dr. Kharrazian is a recognized leader, that it is growing in both its adoption and successful application to the treatment of complex chronic diseases. It is truly a pleasure to call Dr. Kharrazian both a colleague and friend in our mutual advocacy in the development and application of Functional Medicine.

CO-FOUNDER, INSTITUTE OF FUNCTIONAL MEDICINE
PRESIDENT, PERSONALIZED LIFESTYLE MEDICINE INSTITUTE

Why is Dr. Kharrazian’s Chronic Inflammation course different?

Dr. Kharrazian is an actual clinician who has been successfully treating chronic inflammation in the United States and Europe for more than 20 years.

Dr. Kharrazian has witnessed countless real-life patient scenarios and developed proven strategies to address commonly overlooked issues.

Dr. Kharrazian is both a scientist and an educator.

Dr. Kharrazian has been an innovator in the field of functional medicine since its inception.

Dr. Kharrazian stays continually up-to-date with the latest scientific and medical research.

Dr. Kharrazian was trained as a clinical investigator (Master of Medical Science in Clinical Investigation) at Harvard Medical School and can effectively share with you the most relevant research.

Dr. Kharrazian has published a number of immunology studies in the most respected medical journals in the world.

DAVE PERLMUTTER, MD, FACN, ABIHM

Dr. Kharrazian’s work represents the vanguard in our understanding of the role of lifestyle choices in charting the brain’s destiny. His highly effective educational outreach has opened the door for countless healthcare providers, allowing them to dramatically increase their effectiveness in treating and indeed preventing so many of the pernicious conditions that plague our modern society.

AUTHOR, #1 NEW YORK TIMES BESTSELLING BOOK,
GRAIN BRAIN AND BRAIN MAKER

KELLY BROGAN, MD, ABIHM

Dr. Datis Kharrazian is one of the most powerful clinicians of our time. From the lab to the clinic, he has studied, vetted, and applied his cutting-edge science to heal patients all over the world. I consider him to be a foremost authority in a systems approach to recovery and wellness.

AUTHOR, NEW YORK TIMES BESTSELLING BOOK, A MIND OF YOUR OWN

TERRY WAHLS, MD, IFMCP

Dr. Kharrazian is a brilliant clinician educator who has inspired many, myself included. He is superb at teaching clinicians the power of using functional medicine-oriented history and physical examination to understand and address the root causes of disease and health. Integrating the latest research and years of clinical experience, Dr. Kharrazian, is an international leader in Functional Medicine.

NEW YORK TIMES BEST SELLING AUTHOR OF THE WAHLS PROTOCOL – HOW I BEAT
PROGRESSIVE MS USING PALEO PRINCIPLES AND FUNCTIONAL MEDICINE
CLINICAL PROFESSOR OF MEDICINE, UNIVERSITY OF IOWA, CARVER COLLEGE OF MEDICINE

On Demand Registration

Chronic Inflammation Clinical Strategies and Treatment Applications

Welcome to ON DEMAND registration for KI Course Sixteen – Chronic Inflammation. After registration, you will have one-year access to all videos and course materials from the date of your registration. IMPORTANT: You should take the exam in a timely manner in order to get the appropriate credit (if available) from NUHS, or to receive the KI Certificate of Completion.

Current status for CE credits via ON Demand video replays for state licenses is located HERE.

CLICK HERE TO READ PRICING INFORMATION FOR REGISTRANTS

Kharrazian Institute Chronic Inflammation Course Registration Fees

$495 ON DEMAND: 1-year access to all materials

Any registrant can renew access to any course for an additional year for a $100.00 fee instead of the original registration fee.

Student discounts are no longer available.

CLICK HERE TO READ GENERAL ATTENDANCE INFORMATION

Viewing the video content in a group setting will not give you credit for the course. To qualify for credit, you must watch the entire program on your personal computer with your registration email. All online attendance is tracked by our website. KI can only supply minimal attendance information. Please keep track of what you have watched and what you are missing for each module.

Browser update: Recommended browsers for these courses and exams are Safari, Firefox, Edge, and Chrome. Internet Explorer is not recommended. Please update to the newest version of your preferred web browser. If you experience unsatisfactory playback during the live streaming presentation, you may need to restart your computer. Best practice is to restart your computer before the live presentation and avoid unnecessary open applications.

Please note: Your registration email becomes your username for all KI courses and your password will remain the same for all courses. Please prevent auto-fill mistakes on the registration form. Your should use the same registration email for all courses and all required exams. Please do not modify your browser preferences to block cookies or tracking as it may delay credit. Default browser settings are best for all online courses.

Important Notice: Each registration email (username) is intended for an individual user. If multiple users access your KI account from various locations (as tracked by the website), your account will be suspended and all course credits will be voided without refund. Sharing or selling content will void all course credits with no refund.

CLICK HERE TO READ ABOUT CREDIT CARD PROCESSING

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ON DEMAND Registration
Chronic Inflammation Course

This checkout button below reserves ON DEMAND access to Course Sixteen on the KI Learning website for all course materials, videos, testing, and transcripts. After registration, you will have a one-year access to all materials from the date of your registration. If you have questions, please email us HERE.

PLEASE NOTE: IF YOU HAVE AN ACTIVE KI SUBSCRIPTION, YOU DO NOT NEED TO REGISTER FOR THIS COURSE AS YOU WILL HAVE ACCESS TO THE LIVESTREAM AND ON DEMAND REPLAYS AFTER THE LIVESTREAM AS LONG AS YOUR SUBSCRIPTION IS ACTIVE.

IMPORTANT NOTE: After registration, you will receive an email titled Important Login Info: Kharrazian Institute… which contains your login credentials for immediate access to all course materials and videos. After watching all videos and successfully completing the online examinations for each course, you will receive a “KI Certificate of Completion”. Otherwise, you are incomplete for the course.

CE Credits and KI Certificate of Completion

Please complete the KI course before you order the CE Credits from National University. You are NOT complete for the course unless you pass both primary exams AND watch the livestream or all videos for both days AND after you have received the KI Certificate of Completion. Attendance via onsite live (when available) does not require exams.

When requesting an attendance verification from NUHS, registrants will need to list the title of the course(s) for which they’d like an attendance verification and through whom they took the course(s): Kharrazian Institute.

Testimonials about the Kharrazian Institute courses

– Carri

The very first course I attended with Dr. Kharrazian was his Functional Endocrinology course back in 2003 and boy did that ever rock my world. His Kharrazian Institute Neuroinflammation course just did the same thing… but on a MUCH larger scale. It’s a total game changer. Paradigm shifting. I’m 20+ years in practice and I’ve noticed patients are getting so much harder to treat, with much more complex and chronic issues, and now I have a much better understanding why and what to do about it! Dr. K — thank you for putting this revolutionary information together!

– Christopher

I’ve practiced 23 years and one of my biggest pet peeves was “shooting blind.” By this I mean, “It’s been determined by years of clinical use that such and such a remedy is good for the treatment of X.” I always felt inadequate, exposed, and unsure of the variables. I can’t express in words the degree of appreciation I have for your dedication to determining mechanisms, researching studies, and most importantly breaking down this disparate information into readily accessible and mostly easy to understand, maps of malfunctioning physiology. I have found it invaluable. As you repeatedly stressed at your Functional Neurology Seminars program in the past, it’s sloppy clinical work to proceed with treatment until a clear picture of where the dominos fell first is figured out, so the appropriate treatment is arrived at. A million thanks to a fabulous contributor.

– Steven

This seminar was more eye opening about why some of these chronic failures we’ve all had as practitioners need more of a neuro-metabolic approach and to give yourself and the patient time and give realistic expectations so we both don’t get burned out or disappointed. That was huge for me. Thanks Dr. Kharrazian.

– Diego

This has been a freaking gorgeous course. Looking forward to the digestive health course in September.

– Xavier

What a blessing to have been able to follow that neuroinflammation course. Full of scientific data but lots of clinical applications that are very helpful for practitioners. I’m very happy to be able to follow that course since nothing is available like this in France. This should be taught in med school. Thank you Dr. Datis Kharrazian!

– Judy

What a brilliant lecture and very clinical. Hammering home the points and reviewing while we went along really prepared me for the exam. So practical and I will be attending the next two in the series. Very well done. Really can’t say enough good things today. Thanks to everyone involved to pull it off and make livestream possible for me here in Canada.

– Greg

Dr. Kharrazian has literally given me hope and if I could use one word to describe my weekend it would be “PROFOUND”. I am truly grateful for you!!!

– Lapis

Thanks for the excellent, clinically translatable course; with much appreciation for the lucid organization and abundant supportive documents.

More testimonials

PEDRAM SHOJAI, OMD

Dr. Kharrazian is one of the greatest minds in the functional medicine space. He’s a trailblazer and an innovator. His courses are gold and his direction is wise. If you’re in healthcare and are ready to be on the right side of history, study with this man.
AUTHOR, NEW YORK TIMES BESTSELLING BOOK, THE URBAN MONK
FOUNDER OF WELL.ORG

DAVID MUSNICK, MD

Dr. Kharrazian is one of the most skilled Functional medicine practitioners in the country. His understanding of interrelationships in physiology puts him in the top tier of Functional Medicine writers and educators in this country.
FACULTY OF THE INSTITUTE FOR FUNCTIONAL MEDICINE

NORA GEDGAUDAS, CNS, NTP, BCHN

Datis Kharrazian is truly among the great medical geniuses of our time. His capacity to think outside the box is second to none. He brings cutting-edge insights to the table that others have missed along the way and for this we should be eternally grateful.
AUTHOR, PRIMAL BODY, PRIMAL MIND AND PRIMAL FAT BURNER

ELIZABETH BOHAM, MD, RD

Dr. Kharrazian is a leader in functional medicine, always looking to discover the root cause of illness or dysfunction in the body and, most importantly, uncovering novel therapies to improve optimal function.
MEDICAL DIRECTOR OF THE ULTRAWELLNESS CENTER

MARK FLANNERY, DC, MS, BS

Dr. Kharrazian’s education gave me the knowledge and confidence to take on complicated chronic cases. I would not have the patient success I have without the information I gained from Dr. Kharrazian. I have taken many seminars by many different doctors but I could not do what I do without the knowledge I gained from Dr. Kharrazian.
DIRECTOR OF HEALTH WISE CLINICAL NUTRITION

JOSHUA REDD, DC, MS

Dr. Kharrazian’s education has been pivotal in every aspect of my practice. His curriculum has been my foundation for building seven thriving functional medicine clinics. I couldn’t ask for a more rewarding career path.
FOUNDER OF RED RIVER HEALTH AND WELLNESS CENTER
AUTHOR, THE TRUTH ABOUT LOW THYROID

SHANE STEADMAN, DC, DACNB, DCBCN, CNS

In the last decade, I have seen Dr. Kharrazian change the landscape of healthcare. His ability to integrate functional medicine, immunology, and neurology is second to none. Individuals like Dr. Kharrazian come around once in a lifetime. I could not be more honored to learn from him and consider him to be a wonderful mentor. I sincerely believe the Kharrazian Institute will continue to evolve health care.
DIRECTOR, INTEGRATED HEALTH SYSTEMS AND INTEGRATED BRAIN CENTERS

PEARL ZIMMERMAN, MD, MPH

Dr. Kharrazian’s teachings have made more of a difference than anything else I’ve studied. His way of explaining things has been the most clear and relevant and his treatment recommendations the most efficient and effective. I’m thankful beyond words for all he’s contributed to both my personal health and my professional growth.
PHYSICIAN, UNIVERSITY OF CALIFORNIA IRVINE INTEGRATIVE HEALTH INSTITUTE