Session 1: Introduction to Degenerative Joint and Bone Conditions (60 minutes)
Lecture Description: This presentation will review metabolic and endocrine functions of the musculoskeletal system. The metabolic impact of physical activity and health and recovery will also be discussed, with particular attention to myokine and exerkine physiology. The physiological impact of sedentary activity will be reviewed.
- Metabolic and endocrine functions of the musculoskeletal system
– Bone
– Structural support
– Mineral storage
– Hematopoiesis
– Osteocyte endocrine regulation
– Toxic element reservoir
– Muscle
– Support and movement
– Temperature regulation
– Myokine endocrine regulation
– Joint
– Movement and stability
- The metabolic impact of physical activity on health and recovery
– Activation of myokines on systemic physiology
– Activation of exerkines on systemic physiology
– Mechanisms of recovery from physical activity
– Promotion of microbiome diversity
– Stimulation of mitochondria biogenesis and mitophagy
– Activation of regenerative hormones
– Dampening of systemic inflammation
– Enhancement of immune function
– Insulin release and signaling modulation
– Neuron branching
– Vasoactive peptide release
- The impact of injury and lack of physical activity
– Reduced healing potential
– Promotion of inflammation
– Depression and mood changes
- Conventional and functional medicine approaches to muscle, bone, and joint conditions in healthcare today
Session 2: Systemic Biology Interactions with Degenerative Joint and Bone Conditions (60 Minutes)
Lecture Description: This presentation will discuss variables that impact musculoskeletal degeneration and recovery. The role of systemic inflammation on joint, muscle, and bone physiology will be reviewed. Interventions such as regenerative medicine, lifestyle medicine, and functional medicine will be presented.
- Introduction to Systems Biology Approach
– Promotion of deterioration versus of the factors that promote regeneration and recovery of tissue
– Acute versus chronic inflammation
– Pathophysiology of chronic inflammation
- Factors that promote deterioration of joint, muscle, and bone tissues
– Inflammation
– Body mass index imbalance
– Sedentary activity
– Inflammaging
– Insulin surges
– Dietary prostaglandin imbalance
– Toxic chemical exposure
– Impaired toxic chemical clearance
– Depleted antioxidant reserves
– Microbiome dysfunction
– Chronic infection
– Intestinal permeability
– Pulmonary permeability
– Loss of immune tolerance
– Dietary protein reactivity
– Chemical immunological reactivity
– Autoimmunity
- Factors that support regeneration and recovery of joint, bone, and muscle tissues
– Nutraceuticals to support bone, muscle, and cartilage regeneration
– Adequate protein intake
– Hormones
– Myokines and exerkines
– Sleep
– Regenerative medicine strategies for tissue repair
– Prolotherapy (dextrose) injections
– Platelet-rich plasma (PRP) therapy injections
– Hyaluronic acid therapy injections
– Stem cell therapy injections
– Biohacking therapies
– Cryotherapy
– Thermotherapy
– Red light therapy
– Cold laser therapy
Session 3 – Degenerative Joint Conditions — 60 minutes
Lecture Description: This presentation will review of different types of degenerative joint diseases, which include osteoarthritis, autoimmune arthritis, and gout. A review of conventional and alternative medicine strategies will be presented with their potential strengths and weaknesses. A review of the literature with clinical considerations to how diet, nutrition, and lifestyle medicine strategies impact degenerative joint diseases will be presented.
- Types of degenerative joint diseases A. Osteoarthritis (wear and tear arthritis)
– Joint cartilage degeneration (peripheral joints and spinal facets)
– Spinal disc degeneration
– Knee meniscus degeneration
B. Autoimmune arthritis
– Rheumatoid arthritis
– Psoriatic arthritis
C. Gout
– Primary gout (body produces to much UA or kidneys don’t excrete enough)
– Secondary gout (metabolic disease leads to increased uric acid)
– Kidney disease
– Medications (diuretics, aspirin, immunosuppressants)
– Blood disorders (polycythemia or leukemia)
– Pseudogout (CPDD — calcium pyrophosphate deposition disease)
- Osteoarthritis
– Pathophysiology
– Conventional medicine approaches
– Systems biology approach
– Nutraceuticals (cartilage repair)
– Glucosamine and chondroitin sulfate (1500 mg and 1200 mg per day)
– Hyaluronic acid (300 mg per day)
– Hydrolyzed collagen (10 grams per day)
– Methylsulfonylmethane (MSM) (3 grams per day)
– Boswellia (1000 mg per day)
– Regenerative medicine
- Autoimmune arthritis
– Pathophysiology
– Conventional medicine approaches
– Autoimmune strategies
– Systems biology approach for joints
– Regenerative medicine
- Gout
– Pathophysiology
– Conventional medicine approaches
– Dietary strategies
– Nutraceuticals
– Systems biology approach
– Regenerative medicine approach
Session 4 – Progressive Bone Loss/Osteoporosis — 60 minutes
Lecture Description: This presentation will review the pathophysiology, diagnosis, and conventional approaches to osteoporosis. A review of the literature will be presented that covers dietary, nutritional, and lifestyle approaches to help improve bone density and slow down osteoporosis expression. Laboratory test interpretation for bone density markers and various lab tests to identify risk factors for osteoporosis are presented in this lecture.
-
- Osteoporosis- Pathophysiology of osteoporosis
– Osteoporosis diagnosis
– Clinical approaches to osteoporosis
– Optimizing bone remodeling
– Reducing osteoclast expression
– Activation of osteoblast expression
– Bone mineralization support
– Bone loss clinical evaluation and strategies
– Medical history
– Dietary history
– Lifestyle history
– Labs
– DEXA scan
– Rule out potential pathology that impacts bone remodeling
– Renal, liver, and parathyroid markers
– Vitamin D
– Bone resorption metabolites
– Cross-linked N-telopeptide (urine)
– Collagen type 1 C-telopeptide (serum)
– CRP
– Ferritin
– Homocysteine
– Hormone panels
– Thyroid panel
– Adrenal cortisol profile
– Micronutrient profile
– GI panel
– Intestinal permeability panel
– Oxidative stress profile
Session 5 – Muscle Dysfunction and Aging Muscles — 60 minutes
Lecture Description: This presentation will review the risk factors that lead to sarcopenia and its impact on longevity and wellness. Muscle tissue requirements regarding macronutrients, micronutrients, and exercise will be presented. The pathophysiology of sarcopenia will be presented with a review of the literature and clinical strategies to reduce muscle mass loss and build skeletal muscle.
- The impact of muscles on human health- Muscle is the factor that prevents frailty
– Myokine activities
- Muscle tissue requirements to maintain tissue and function
– Exercise
– Macronutrients
– Protein
– Hydration
– Micronutrients
– Vitamin D
– Essential fatty acids
– Electrolyte support (calcium, magnesium, potassium)
– Creatine
– Selenium
- Aging muscle- Motor unit changes and mitochondria changes in muscle and nerve motor unit- Sarcopenia and associated risk factors from lack of myokines
– Sarcopenia and frailty
– Inflammaging
- Types of chronic muscle conditions
– Dysfunctional muscle metabolism
– Aging muscle
– Statin-induced myopathy
– Abnormal muscle tone
- Dysfunctional muscle metabolism
– Electrolyte and hydration issues — muscle cramping
– Muscle bioenergetic dysfunction — low endurance and deep pain
- Myofascial dysfunction
– Pathophysiology
– Lifestyle patterns that promote myofascial syndromes
– Nutrient imbalances that promote myofascial syndromes
– Muscle weakness leading to chronic myofascial pattern
– Myofascial dysfunction
– Treatment for myofascial patterns
- Abnormal muscle tone- Somatosensory dysfunction and chronic injuries
– Basal ganglia disease and abnormal tone
Session 6 – Physical Activities to Build the Musculoskeletal System — 30 minutes
Lecture Description: This presentation discusses how exercise duration, intensity, and frequency impact skeletal muscle development and bone density. A review of the literature will be summarized in this presentation.
- Review of the literature on exercise duration, intensity, and frequency to build skeletal muscle.
- Review of the literature on exercise duration, intensity, and frequency to build bone density.
Session 7 – Review of Concepts — 15 minutes
Lecture Description: This presentation will review the principles and concepts presented in previous discussions about joint, muscle, and bone degenerations. Connections will be made with how these systems interrelate and the common features of lifestyle strategies necessary to improve musculoskeletal health.
- Review the principles and physiological concepts of joint, muscle, and bone degenerative conditions.
- Review clinical evaluation and strategies for joint, muscle, and bone degenerative conditions.
Session 8 — Clinical Case Examples — 15 minutes
Lecture Description: This presentation will present clinical cases of sarcopenia, arthritis, and osteoporosis. The diagnostic features of each case will be emphasized. Clinical strategies to incorporate evidence-based strategies to support these clinical cases will be presented.
- Clinical case example of sarcopenia
- Clinical case example of arthritis
- Clinical case example of osteoporosis
