“It’s time to stop letting outdated studies from the Women’s Health Initiative prevent us from offering evidence-based hormone therapy to appropriate candidates.” — Dr. Mark Holthouse.

The latest research reveals a deeper understanding that could transform your approach to treating postmenopausal women:

• The Women’s Health Initiative has prevented countless women from receiving beneficial hormone therapy. Learn the new research and protocols.
• HRT may reduce Alzheimer’s risk by 30 percent when started within 5 years of menopause.
• HRT delivers a significant reduction in atherosclerosis progression with early intervention.
• Fracture risk decreases by 30-40 percent at all sites, with benefits persisting beyond age 60.
• Natural progesterone offers unique neuroprotective benefits and myelin repair support.
• Different delivery systems significantly affect treatment outcomes.

Holthouse guides you through sophisticated protocols for patient selection, monitoring, and risk stratification, allowing you to confidently offer hormone therapy.

Through Dr. Holthouse’s “pothole” analogy, you’ll understand bone remodeling processes and develop clear criteria for optimal interventions. Based on current evidence, you’ll learn to distinguish between various HRT formulations and their delivery methods while implementing personalized treatment protocols.

“When I see a premenopausal consult under age 35 in my office, over 75 percent are PCOS cases.” — Dr. Holthouse.

PCOS is a complex condition that demands more than standard metformin and birth control prescriptions.

Through years of clinical experience, Dr. Holthouse has developed targeted protocols that address underlying metabolic dysfunction while supporting natural fertility.

Critical insights about PCOS that will transform your practice:

• Only 11 percent of PCOS patients are obese, yet 90 percent show metabolic dysfunction
• Free testosterone testing proves more reliable than total testosterone
• Anti-Müllerian Hormone (AMH) plays an emerging diagnostic role
• Specific myo-inositol and D-chiro-inositol ratios deliver optimal results
• Progesterone therapy requires precise timing and dosing strategies

The course extends beyond PCOS to address the full spectrum of premenopausal conditions. You’ll discover why PMS and PMDD demand more sophisticated approaches than SSRI prescriptions. Dr. Holthouse explains the critical role of GABA receptor sensitivity and progesterone metabolites in brain function while sharing practical protocols for managing menorrhagia and optimizing ferritin levels.

Understanding the connection between inflammation and hormonal balance becomes crucial when approaching heavy menstrual bleeding.

Mounting evidence suggests we’re undertreating many women who could benefit from testosterone therapy.

A groundbreaking study revealed significantly lower rates of invasive breast cancer in women receiving testosterone therapy compared to controls.

Drawing from landmark studies, Dr. Holthouse addresses common concerns about testosterone therapy and breast health, cardiovascular effects, bone health, and neurological and metabolic impacts.

Key aspects of successful female testosterone therapy:

• Transdermal applications at 150-300 micrograms daily show optimal results
• Individual response matters more than standard reference ranges
• Some women maintain adequate levels into their 90s, while others drop in their 40s
• Laboratory values must be interpreted within a comprehensive clinical framework
• Monitoring strategies extend beyond basic lab work

Clinicians are now routinely seeing low testosterone and erectile dysfunction in men in their 30s.

A recent study showed 50 percent lower testosterone in obese teenage boys.

Newer research has revolutionized our understanding of testosterone therapy’s safety profile. Dr. Holthouse walks you through landmark findings that challenge previous assumptions about testosterone replacement, including new evidence suggesting the 2015 FDA black box warning may soon be removed.

Crucial insights for treating male patients include:

• No reliable testosterone threshold predicts therapy response
• Age alone should not contraindicate treatment
• Proper optimization supports cardiovascular health
• The relationship between testosterone and metabolic health runs deeper than previously thought
• Fertility preservation requires sophisticated protocols in younger men

Seventy percent of men with adult-onset hypogonadism have cardiometabolic syndrome, while 20-50 percent of diabetic patients show low testosterone.

Dr. Holthouse’s innovative “Magnificent 7” protocol addresses these connections, supporting natural testosterone production while managing underlying metabolic dysfunction.

“The gut should be one of the first things you consider when evaluating hormone health.” — Dr. Holthouse.

Research shows that leaky gut syndrome can actively sabotage hormone optimization efforts.

Through years of clinical experience, Dr. Holthouse has developed sophisticated protocols that address gut-hormone axis. You’ll learn specific approaches to healing gut barriers, modulating inflammation, and supporting healthy hormone metabolism.

The emerging GELDING theory (Gut Endotoxin Leading to Decline In Gonadal Function) reveals why treating the gut may be crucial for optimal hormone levels.

This isn’t theoretical education—you’ll receive comprehensive assessment tools, laboratory algorithms, supplement recommendations, and detailed treatment timelines. Dr. Holthouse shares his protocols in his successful multi-state practice, allowing you to implement these strategies immediately.

Transform your approach to hormone optimization and provide more comprehensive care options for your patients.

“We’re seeing an epidemic of early menarche driven by environmental xenoestrogens.” — Dr. Holthouse

Understanding the impact of toxins is crucial for modern women’s health.

This course provides practical frameworks for assessing toxic burden through functional testing while implementing detoxification strategies that support healthy estrogen metabolism.

Environmental toxins create a complex web of hormonal disruption, particularly affecting young girls. Dr. Holthouse shares protocols for protecting patients from ongoing exposure while supporting natural hormonal development.

You’ll learn precise approaches to using DIM and calcium D-glucarate, supporting methylation pathways, and optimizing liver detoxification.

1. Progesterone Use in Common Premenopausal Conditions (60 Minutes)
2. Testosterone Optimization in Pre-, Peri- and Postmenopausal Women (30 Minutes)
3. Rethinking Hormone Replacement Therapy in Postmenopausal Women (75 minutes)
   • Cardio-metabolic disease implications
   • Osteoporosis/Osteopenia
   • Cognitive decline
   • Breast cancer risk with HRT
   • HRT and collagen considerations
4. A Practical Approach to Testosterone in Men (145 Minutes)